EC number:2.1.1.71
| ID: | 2.1.1.71 |
|---|---|
| Description: | Phosphatidyl-N-methylethanolamine N-methyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.71 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.71 |
| KEGG Enzyme Link: | KEGG2.1.1.71 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.71 |
| ExPASy Enzyme Link: | ExPASy2.1.1.71 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.71 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.71 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.71 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.71 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.71 |
| RHEA:32739 | 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[N;H0;+0:2](-[*:3])-[*:4].[*:5]-[S+;H0:6](-[*:7])-[CH3;+0:8]>>[*:1]-[N+;H0:2](-[*:3])(-[*:4])-[CH3;+0:8].[*:5]-[S;H0;+0:6]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Yeast phosphatidylethanolamine methylation pathway. Cloning and characterization of two distinct methyltransferase genes. | Kodaki T, Yamashita S | 1987 Nov 15 | 2445736 |
| Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis. | Palavalli LH, Brendza KM, Haakenson W, Cahoon RE, McLaird M, Hicks LM, McCarter JP, Williams DJ, Hresko MC, Jez JM | 2006 May 16 | 16681378 |
| RHEA:32735 | 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[*:3].[*:4]-[S+;H0:5](-[*:6])-[CH3;+0:7]>>[*:1]-[N;H0;+0:2](-[*:3])-[CH3;+0:7].[*:4]-[S;H0;+0:5]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities. | Schneider WJ, Vance DE | 1979 May 25 | 438165 |
| Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine. | Hirata F, Viveros OH, Diliberto EJ Jr, Axelrod J | 1978 Apr | 25437 |
| Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis. | Palavalli LH, Brendza KM, Haakenson W, Cahoon RE, McLaird M, Hicks LM, McCarter JP, Williams DJ, Hresko MC, Jez JM | 2006 May 16 | 16681378 |