EC number:2.1.1.72

Enzyme

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     2. Transferases
        2.1 Transferring one-carbon groups
            2.1.1 Methyltransferases
ID:2.1.1.72
Description:Site-specific DNA-methyltransferase (adenine-specific).
Alternative Name: Restriction-modification system.
N-6 adenine-specific DNA methylase.
Modification methylase.
Prosite: PDOC00087;
PDB:
PDBScop
4BLW 8086268; 8086269; 8086268; 8086269;
4BLV 8086268; 8086269; 8086268; 8086269;
4BLU 8086268; 8086269; 8086268; 8086269;
4GOO 8071809; 8071810; 8071809; 8071810; 8071809; 8071810;
4GON 8071809; 8071810; 8071809; 8071810; 8071809; 8071810;
 » show all
Cath: 1.10.10.2110; 1.10.1020.10; 1.20.1260.30; 3.90.1570.50; 3.90.220.10; 3.90.640.50; 1.20.58.2040; 3.40.50.150; 3.40.50.300;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.1.1.72
BRENDA Enzyme Link: BRENDA 2.1.1.72
KEGG Enzyme Link: KEGG2.1.1.72
BioCyc Enzyme Link: BioCyc 2.1.1.72
ExPASy Enzyme Link: ExPASy2.1.1.72
EC2PDB Enzyme Link: EC2PDB 2.1.1.72
ExplorEnz Enzyme Link: ExplorEnz 2.1.1.72
PRIAM enzyme-specific profiles Link: PRIAM 2.1.1.72
IntEnz Enzyme Link: IntEnz 2.1.1.72
MEDLINE Enzyme Link: MEDLINE 2.1.1.72

EC number:2.1.1.72

MSA:

2.1.1.72;
Phylogenetic Tree:

2.1.1.72;
Uniprot:
M-CSA:
RHEA:15197 a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[NH;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Phage T4 DNA [N6-adenine]methyltransferase. Overexpression, purification, and characterization.Kossykh VG, Schlagman SL, Hattman S1995 Jun 167782299
Structure and mechanism of multifunctional restriction endonucleases.Yuan R19816267988
Specificity of restriction endonucleases and DNA modification methyltransferases a review (Edition 3).Kessler C, Manta V1990 Aug 162172084
Restriction enzymes and their isoschizomers.Roberts RJ1990 Apr 252159140
YhdJ, a nonessential CcrM-like DNA methyltransferase of Escherichia coli and Salmonella enterica.Broadbent SE, Balbontin R, Casadesus J, Marinus MG, van der Woude M2007 Jun17400740
N<sup>6</sup>-Methyladenine DNA Modification in the Human Genome.Xiao CL, Zhu S, He M, Chen, Zhang Q, Chen Y, Yu G, Liu J, Xie SQ, Luo F, Liang Z, Wang DP, Bo XC, Gu XF, Wang K, Yan GR2018 Jul 1930017583