EC number:2.1.1.99
| ID: | 2.1.1.99 |
|---|---|
| Description: | 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase. |
| Alternative Name: |
N-methyltransferase. S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine NMT. 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase. 16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.1.99 |
| BRENDA Enzyme Link: | BRENDA 2.1.1.99 |
| KEGG Enzyme Link: | KEGG2.1.1.99 |
| BioCyc Enzyme Link: | BioCyc 2.1.1.99 |
| ExPASy Enzyme Link: | ExPASy2.1.1.99 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.1.99 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.1.99 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.1.99 |
| IntEnz Enzyme Link: | IntEnz 2.1.1.99 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.1.99 |
| RHEA:11336 | (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = deacetoxyvindoline + H(+) + S-adenosyl-L-homocysteine |
| RULE(radius=1) | [*:1]-[NH;+0:2]-[*:3].[*:4]-[S+;H0:5](-[*:6])-[CH3;+0:7]>>[*:1]-[N;H0;+0:2](-[*:3])-[CH3;+0:7].[*:4]-[S;H0;+0:5]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ-dependent manner in Catharanthus roseus. | Besseau S, Kellner F, Lanoue A, Thamm AM, Salim V, Schneider B, Geu-Flores F, Höfer R, Guirimand G, Guihur A, Oudin A, Glevarec G, Foureau E, Papon N, Clastre M, Giglioli-Guivarc'h N, St-Pierre B, Werck-Reichhart D, Burlat V, De Luca V, O'Connor SE, Courdavault V | 2013 Dec | 24108213 |
| A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus. | Liscombe DK, O'Connor SE | 2011 Nov | 21802100 |
| Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis. | Liscombe DK, Usera AR, O'Connor SE | 2010 Nov 2 | 20956330 |