EC number:2.1.1.n8
| ID: | 2.1.1.n8 |
|---|---|
| Description: | Small RNA 2'-O-methyltransferase. |
| Cath: | 3.30.160.20; 3.40.50.150; |
3D structure
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| RHEA:37887 | S-adenosyl-L-methionine + small RNA = H(+) + S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6]>>[*:1]-[O;H0;+0:2]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural insights into mechanisms of the small RNA methyltransferase HEN1. | Huang Y, Ji L, Huang Q, Vassylyev DG, Chen X, Ma JB | 2009 Oct 8 | 19812675 |
| 2'-O-methylation stabilizes Piwi-associated small RNAs and ensures DNA elimination in Tetrahymena. | Kurth HM, Mochizuki K | 2009 Apr | 19240163 |
| Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis. | Li J, Yang Z, Yu B, Liu J, Chen X | 2005 Aug 23 | 16111943 |
| Methylation as a crucial step in plant microRNA biogenesis. | Yu B, Yang Z, Li J, Minakhina S, Yang M, Padgett RW, Steward R, Chen X | 2005 Feb 11 | 15705854 |