EC number:2.1.2.2
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.1 Transferring one-carbon groups |
| 2.1.2 Hydroxymethyl-, formyl- and related transferases |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.2.2 |
| BRENDA Enzyme Link: | BRENDA 2.1.2.2 |
| KEGG Enzyme Link: | KEGG2.1.2.2 |
| BioCyc Enzyme Link: | BioCyc 2.1.2.2 |
| ExPASy Enzyme Link: | ExPASy2.1.2.2 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.2.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.2.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.2.2 |
| IntEnz Enzyme Link: | IntEnz 2.1.2.2 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.2.2 |
| RHEA:15053 | (6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[CH;+0:4]-[N;H0;+0:5](-[*:6])-[*:7]>>[*:6]-[NH;+0:5]-[*:7].[*:3]=[CH;+0:4]-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| L(-)-10-Formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver. | Smith GK, Benkovic PA, Benkovic SJ | 1981 Jul 7 | 7284307 |
| N10-Formyltetrahydrofolate is the formyl donor for glycinamide ribotide transformylase in Escherichia coli. | Dev IK, Harvey RJ | 1978 Jun 25 | 350869 |
| Subcloning, characterization, and affinity labeling of Escherichia coli glycinamide ribonucleotide transformylase. | Inglese J, Johnson DL, Shiau A, Smith JM, Benkovic SJ | 1990 Feb 13 | 2185839 |
| Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes. | Manieri W, Moore ME, Soellner MB, Tsang P, Caperelli CA | 2007 Jan 9 | 17198385 |
| Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reactions. | HARTMAN SC, BUCHANAN JM | 1959 Jul | 13672969 |
| Biosynthesis of the purines. XIX. 2-Amino-N-ribosylacetamide 5'-phosphate (glycinamide ribotide) transformylase. | WARREN L, BUCHANAN JM | 1957 Dec | 13502326 |