EC number:2.1.2.3
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.1 Transferring one-carbon groups |
| 2.1.2 Hydroxymethyl-, formyl- and related transferases |
| ID: | 2.1.2.3 |
|---|---|
| Description: | Phosphoribosylaminoimidazolecarboxamide formyltransferase. |
| Alternative Name: |
Aminoimidazolecarboxamide ribonucleotide transformylase. AICAR transformylase. AICAR formyltransferase. 5-amino-4-imidazolecarboxamide ribotide transformylase. 5-amino-4-imidazolecarboxamide ribonucleotide transformylase. 5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase. 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase. imidazolecarboxamide formyltransferase. 10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4- |
| Cath: | 1.10.287.440; 3.30.1490.20; 3.30.470.20; 3.40.140.20; 3.40.50.1380; 3.40.50.20; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.2.3 |
| BRENDA Enzyme Link: | BRENDA 2.1.2.3 |
| KEGG Enzyme Link: | KEGG2.1.2.3 |
| BioCyc Enzyme Link: | BioCyc 2.1.2.3 |
| ExPASy Enzyme Link: | ExPASy2.1.2.3 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.2.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.2.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.2.3 |
| IntEnz Enzyme Link: | IntEnz 2.1.2.3 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.2.3 |
| RHEA:22192 | (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[CH;+0:4]-[N;H0;+0:5](-[*:6])-[*:7]>>[*:6]-[NH;+0:5]-[*:7].[*:3]=[CH;+0:4]-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping. | Rayl EA, Moroson BA, Beardsley GP | 1996 Jan 26 | 8567683 |
| Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reactions. | HARTMAN SC, BUCHANAN JM | 1959 Jul | 13672969 |