EC number:2.1.2.5
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.1 Transferring one-carbon groups |
| 2.1.2 Hydroxymethyl-, formyl- and related transferases |
| ID: | 2.1.2.5 |
|---|---|
| Description: | Glutamate formimidoyltransferase. |
| Alternative Name: |
Glutamate formyltransferase. Glutamate formiminotransferase. Formiminoglutamic formiminotransferase. Formiminoglutamic acid transferase. |
| Cath: | 1.20.120.680; 3.30.70.670; 3.30.990.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.1.2.5 |
| BRENDA Enzyme Link: | BRENDA 2.1.2.5 |
| KEGG Enzyme Link: | KEGG2.1.2.5 |
| BioCyc Enzyme Link: | BioCyc 2.1.2.5 |
| ExPASy Enzyme Link: | ExPASy2.1.2.5 |
| EC2PDB Enzyme Link: | EC2PDB 2.1.2.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.1.2.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.1.2.5 |
| IntEnz Enzyme Link: | IntEnz 2.1.2.5 |
| MEDLINE Enzyme Link: | MEDLINE 2.1.2.5 |
| RHEA:23240 | 5-formyltetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-glutamate |
| RULE(radius=1) | [*:1]-[N;H0;+0:2](-[*:3])-[CH;+0:4]=[*:5].[*:6]-[NH2;+0:7]>>[*:1]-[NH;+0:2]-[*:3].[*:5]=[CH;+0:4]-[NH;+0:7]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Moonlighting glutamate formiminotransferases can functionally replace 5-formyltetrahydrofolate cycloligase. | Jeanguenin L, Lara-Núñez A, Pribat A, Mageroy MH, Gregory JF 3rd, Rice KC, de Crécy-Lagard V, Hanson AD | 2010 Dec 31 | 20952389 |
| RHEA:15097 | 5-formimidoyltetrahydrofolate + L-glutamate = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoyl-L-glutamate |
| RULE(radius=1) | [*:1]-[N;H0;+0:2](-[*:3])-[CH;+0:4]=[*:5].[*:6]-[NH2;+0:7]>>[*:1]-[NH;+0:2]-[*:3].[*:5]=[CH;+0:4]-[NH;+0:7]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The nucleotide sequence of porcine formiminotransferase cyclodeaminase. Expression and purification from Escherichia coli. | Murley LL, Mejia NR, MacKenzie RE | 1993 Oct 25 | 7901203 |
| Moonlighting glutamate formiminotransferases can functionally replace 5-formyltetrahydrofolate cycloligase. | Jeanguenin L, Lara-Núñez A, Pribat A, Mageroy MH, Gregory JF 3rd, Rice KC, de Crécy-Lagard V, Hanson AD | 2010 Dec 31 | 20952389 |
| The molecular basis of glutamate formiminotransferase deficiency. | Hilton JF, Christensen KE, Watkins D, Raby BA, Renaud Y, de la Luna S, Estivill X, MacKenzie RE, Hudson TJ, Rosenblatt DS | 2003 Jul | 12815595 |
| Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency. | Solans A, Estivill X, de la Luna S | 2000 | 10773664 |