EC number:2.2.1.5
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.2 Transferring aldehyde or ketonic groups |
| 2.2.1 Transketolases and transaldolases |
| ID: | 2.2.1.5 |
|---|---|
| Description: | 2-hydroxy-3-oxoadipate synthase. |
| Alternative Name: |
Oxoglutarate: glyoxylate carboligase. Alpha-ketoglutaric-glyoxylic carboligase. 2-hydroxy-3-oxoadipate synthetase. 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating). |
| Cath: | 1.10.287.1150; 3.40.50.970; 3.40.50.11610; 3.40.50.12470; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.2.1.5 |
| BRENDA Enzyme Link: | BRENDA 2.2.1.5 |
| KEGG Enzyme Link: | KEGG2.2.1.5 |
| BioCyc Enzyme Link: | BioCyc 2.2.1.5 |
| ExPASy Enzyme Link: | ExPASy2.2.1.5 |
| EC2PDB Enzyme Link: | EC2PDB 2.2.1.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.2.1.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.2.1.5 |
| IntEnz Enzyme Link: | IntEnz 2.2.1.5 |
| MEDLINE Enzyme Link: | MEDLINE 2.2.1.5 |
| RHEA:14341 | 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO2 |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]=[C;H0;+0:5](-[OH;+0:6])-[C;H0;+0:7](=[*:8])-[*:9].[H+;H0:10]>>[*:1]-[CH;+0:2](-[OH;+0:3])-[C;H0;+0:7](=[*:8])-[*:9].[*:4]=[C;H0;+0:5]=[O;H0;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Carboligase activity of alpha-ketoglutarate dehydrogenase. | Schlossberg MA, Bloom RJ, Richert DA, Westerfeld WW | 1970 Mar 3 | 5418712 |
| Purification, general properties and two other catalytic activities of -ketoglutarate:glyoxylate carboligase of Mycobacterium Phlei. | Yamasaki H, Moriyama T | 1971 Sep 22 | 5003720 |
| Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate: glyoxylate carboligase. | Schlossberg MA, Richert DA, Bloom RJ, Westerfeld WW | 1968 Jan | 4320439 |
| Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism. | Wagner T, Bellinzoni M, Wehenkel A, O'Hare HM, Alzari PM | 2011 Aug 26 | 21867916 |
| The synergistic decarboxylation of glyoxylate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria. | Stewart PR, Quayle JR | 1967 Mar | 16742506 |