EC number:2.3.1.1
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.1 |
|---|---|
| Description: | Amino-acid N-acetyltransferase. |
| Alternative Name: |
N-acetylglutamate synthase. |
| Cath: | 3.30.2330.10; 3.40.1160.10; 3.40.630.30; 3.60.70.12; 3.10.20.340; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.1 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.1 |
| KEGG Enzyme Link: | KEGG2.3.1.1 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.1 |
| ExPASy Enzyme Link: | ExPASy2.3.1.1 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.1 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.1 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.1 |
| RHEA:24292 | acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of acetyl-CoA:L-glutamate N-acetyltransferase from human liver. | Bachmann C, Krähenbühl S, Colombo JP | 1982 Jul 1 | 7126172 |
| Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms. | Zhao G, Jin Z, Allewell NM, Tuchman M, Shi D | 2013 | 23894642 |
| Functional characterization of a novel ArgA from Mycobacterium tuberculosis. | Errey JC, Blanchard JS | 2005 May | 15838030 |
| Cloning and expression of the human N-acetylglutamate synthase gene. | Caldovic L, Morizono H, Gracia Panglao M, Gallegos R, Yu X, Shi D, Malamy MH, Allewell NM, Tuchman M | 2002 Dec 13 | 12459178 |
| Identification, cloning and expression of the mouse N-acetylglutamate synthase gene. | Caldovic L, Morizono H, Yu X, Thompson M, Shi D, Gallegos R, Allewell NM, Malamy MH, Tuchman M | 2002 Jun 15 | 12049647 |
| Characterization and kinetic mechanism of mono- and bifunctional ornithine acetyltransferases from thermophilic microorganisms. | Marc F, Weigel P, Legrain C, Almeras Y, Santrot M, Glansdorff N, Sakanyan V | 2000 Aug | 10931207 |