EC number:2.3.1.108
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.108 |
|---|---|
| Description: | Alpha-tubulin N-acetyltransferase. |
| Alternative Name: |
Tubulin N-acetyltransferase. Tubulin acetyltransferase. TAT. Alpha-tubulin acetyltransferase. Alpha-tubulin acetylase. |
| Cath: | 4.10.80.330; 3.40.630.30; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.108 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.108 |
| KEGG Enzyme Link: | KEGG2.3.1.108 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.108 |
| ExPASy Enzyme Link: | ExPASy2.3.1.108 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.108 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.108 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.108 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.108 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.108 |
EC number:2.3.1.108
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:15277 | acetyl-CoA + L-lysyl-[alpha-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[alpha-tubulin] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Alpha-tubulin acetylase activity in isolated Chlamydomonas flagella. | Greer K, Maruta H, L'Hernault SW, Rosenbaum JL | 1985 Dec | 4066751 |
| Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. | Szyk A, Deaconescu AM, Spector J, Goodman B, Valenstein ML, Ziolkowska NE, Kormendi V, Grigorieff N, Roll-Mecak A | 2014 Jun 5 | 24906155 |
| Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules. | Soppina V, Herbstman JF, Skiniotis G, Verhey KJ | 2012 | 23110214 |
| Structure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation. | Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R | 2012 Nov 27 | 23071314 |
| MEC-17 is an alpha-tubulin acetyltransferase. | Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J | 2010 Sep 9 | 20829795 |