EC number:2.3.1.136
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.136 |
|---|---|
| Description: | Polysialic-acid O-acetyltransferase. |
| Cath: | 2.160.10.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.136 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.136 |
| KEGG Enzyme Link: | KEGG2.3.1.136 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.136 |
| ExPASy Enzyme Link: | ExPASy2.3.1.136 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.136 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.136 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.136 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.136 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.136 |
EC number:2.3.1.136
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:11608 | [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S;H0;+0:4]-[C;H0;+0:5](-[CH3;+0:6])=[O;H0;+0:7].[*:8]-[S;H0;+0:9]-[C;H0;+0:10](-[CH3;+0:11])=[O;H0;+0:12].[*:13]-[S;H0;+0:14]-[C;H0;+0:15](-[CH3;+0:16])=[O;H0;+0:17].[*:18]-[S;H0;+0:19]-[C;H0;+0:20](-[CH3;+0:21])=[O;H0;+0:22].[*:23]=[C;H0;+0:24](-[*:25])-[S;H0;+0:26]-[*:27]>>[*:27]-[SH;+0:26].[*:3]-[SH;+0:4].[*:8]-[SH;+0:9].[*:13]-[SH;+0:14].[*:18]-[SH;+0:19].[*:23]=[C;H0;+0:24](-[*:25])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure analysis of the polysialic acid specific O-acetyltransferase NeuO. | Schulz EC, Bergfeld AK, Ficner R, Mühlenhoff M | 2011 Mar 1 | 21390252 |
| Biochemical characterization of the polysialic acid-specific O-acetyltransferase NeuO of Escherichia coli K1. | Bergfeld AK, Claus H, Vogel U, Mühlenhoff M | 2007 Jul 27 | 17519228 |
| Escherichia coli K1 polysialic acid O-acetyltransferase gene, neuO, and the mechanism of capsule form variation involving a mobile contingency locus. | Deszo EL, Steenbergen SM, Freedberg DI, Vimr ER | 2005 Apr 12 | 15809431 |
| RHEA:11604 | [(2->8)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->8)-O(7),N-diacetyl-alpha-D-neuraminosyl](n) + n CoA |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S;H0;+0:4]-[C;H0;+0:5](-[CH3;+0:6])=[O;H0;+0:7].[*:8]-[S;H0;+0:9]-[C;H0;+0:10](-[CH3;+0:11])=[O;H0;+0:12].[*:13]-[S;H0;+0:14]-[C;H0;+0:15](-[CH3;+0:16])=[O;H0;+0:17].[*:18]-[S;H0;+0:19]-[C;H0;+0:20](-[CH3;+0:21])=[O;H0;+0:22].[*:23]=[C;H0;+0:24](-[*:25])-[S;H0;+0:26]-[*:27]>>[*:27]-[SH;+0:26].[*:3]-[SH;+0:4].[*:8]-[SH;+0:9].[*:13]-[SH;+0:14].[*:18]-[SH;+0:19].[*:23]=[C;H0;+0:24](-[*:25])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structure analysis of the polysialic acid specific O-acetyltransferase NeuO. | Schulz EC, Bergfeld AK, Ficner R, Mühlenhoff M | 2011 Mar 1 | 21390252 |
| Biochemical characterization of the polysialic acid-specific O-acetyltransferase NeuO of Escherichia coli K1. | Bergfeld AK, Claus H, Vogel U, Mühlenhoff M | 2007 Jul 27 | 17519228 |
| Escherichia coli K1 polysialic acid O-acetyltransferase gene, neuO, and the mechanism of capsule form variation involving a mobile contingency locus. | Deszo EL, Steenbergen SM, Freedberg DI, Vimr ER | 2005 Apr 12 | 15809431 |