EC number:2.3.1.137
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.137 |
|---|---|
| Description: | Carnitine O-octanoyltransferase. |
| Cath: | 1.10.275.20; 1.20.1280.180; 1.20.5.3450; 3.30.559.10; 3.30.559.40; 3.30.559.70; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.137 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.137 |
| KEGG Enzyme Link: | KEGG2.3.1.137 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.137 |
| ExPASy Enzyme Link: | ExPASy2.3.1.137 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.137 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.137 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.137 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.137 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.137 |
EC number:2.3.1.137
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:17177 | (R)-carnitine + octanoyl-CoA = CoA + O-octanoyl-(R)-carnitine |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Substrate specificity of human carnitine acetyltransferase: Implications for fatty acid and branched-chain amino acid metabolism. | Violante S, Ijlst L, Ruiter J, Koster J, van Lenthe H, Duran M, de Almeida IT, Wanders RJ, Houten SM, Ventura FV | 2013 Jun | 23485643 |
| Structure and function of carnitine acyltransferases. | Jogl G, Hsiao YS, Tong L | 2004 Nov | 15591000 |
| Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. | Jogl G, Hsiao YS, Tong L | 2005 Jan 7 | 15492013 |
| Redesign of carnitine acetyltransferase specificity by protein engineering. | Cordente AG, López-Viñas E, Vázquez MI, Swiegers JH, Pretorius IS, Gómez-Puertas P, Hegardt FG, Asins G, Serra D | 2004 Aug 6 | 15155769 |
| Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids. | Ferdinandusse S, Mulders J, IJlst L, Denis S, Dacremont G, Waterham HR, Wanders RJ | 1999 Sep 16 | 10486279 |
| Carnitine palmitoyltransferase 2: New insights on the substrate specificity and implications for acylcarnitine profiling. | Violante S, Ijlst L, van Lenthe H, de Almeida IT, Wanders RJ, Ventura FV | 2010 Sep | 20538056 |