EC number:2.3.1.169

Enzyme

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EC Tree
     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.169
Description:CO-methylating acetyl-CoA synthase.
Alternative Name: ACS.
Cath: 1.10.1060.10; 1.10.8.190; 1.20.1270.30; 3.20.20.20; 3.30.1650.10; 3.40.970.20; 3.40.1470.10; 3.40.50.20; 3.40.50.2030;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.169
BRENDA Enzyme Link: BRENDA 2.3.1.169
KEGG Enzyme Link: KEGG2.3.1.169
BioCyc Enzyme Link: BioCyc 2.3.1.169
ExPASy Enzyme Link: ExPASy2.3.1.169
EC2PDB Enzyme Link: EC2PDB 2.3.1.169
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.169
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.169
IntEnz Enzyme Link: IntEnz 2.3.1.169
MEDLINE Enzyme Link: MEDLINE 2.3.1.169

EC number:2.3.1.169

MSA:

2.3.1.169;
Phylogenetic Tree:

2.3.1.169;
Uniprot:
M-CSA:
RHEA:45212 [Co(I) corrinoid Fe-S protein] + acetyl-CoA + H(+) = [methyl-Co(III) corrinoid Fe-S protein] + CO + CoA
RULE(radius=1) [*:1]-[S;H0;+0:2]-[C;H0;+0:3](-[CH3;+0:4])=[O;H0;+0:5].[Co+;H0:6].[H+;H0:7]>>[*:1]-[SH;+0:2].[C-;H0:3]#[O+;H0:5].[CH3;+0:4]-[Co+2;H0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Acetyl-CoA decarbonylase/synthase complex from Archaeoglobus fulgidus.Dai YR, Reed DW, Millstein JH, Hartzell PL, Grahame DA, DeMoll E1998 Jun9575239
Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.Ragsdale SW, Wood HG1985 Apr 102984190
Nickel in subunit beta of the acetyl-CoA decarbonylase/synthase multienzyme complex in methanogens. Catalytic properties and evidence for a binuclear Ni-Ni site.Gencic S, Grahame DA2003 Feb 2112464601
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL2002 Oct 1812386327