EC number:2.3.1.175
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.175 |
|---|---|
| Description: | Deacetylcephalosporin-C acetyltransferase. |
| Alternative Name: |
Deacetylcephalosporin C acetyltransferase. DAC-AT. DAC acetyltransferase. CPC acetylhydrolase. Acetyl-CoA:DAC acetyltransferase. Acetyl coenzyme A:DAC acetyltransferase. |
| Cath: | 3.40.50.1820; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.175 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.175 |
| KEGG Enzyme Link: | KEGG2.3.1.175 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.175 |
| ExPASy Enzyme Link: | ExPASy2.3.1.175 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.175 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.175 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.175 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.175 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.175 |
EC number:2.3.1.175
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:23860 | acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins. | Martín JF, Gutiérrez S, Fernández FJ, Velasco J, Fierro F, Marcos AT, Kosalkova K | 1994 | 7847890 |
| Molecular characterization of the Acremonium chrysogenum cefG gene product: the native deacetylcephalosporin C acetyltransferase is not processed into subunits. | Velasco J, Gutierrez S, Campoy S, Martin JF | 1999 Feb 1 | 9895280 |
| Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum. | Gutiérrez S, Velasco J, Marcos AT, Fernández FJ, Fierro F, Barredo JL, Díez B, Martín JF | 1997 Nov | 9421924 |
| Cloning and disruption of the cefG gene encoding acetyl coenzyme A: deacetylcephalosporin C o-acetyltransferase from Acremonium chrysogenum. | Matsuda A, Sugiura H, Matsuyama K, Matsumoto H, Ichikawa S, Komatsu K | 1992 Jul 15 | 1632779 |
| The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase. | Gutiérrez S, Velasco J, Fernandez FJ, Martín JF | 1992 May | 1569032 |
| Purification of acetyl coenzyme A: deacetylacephalosporin C O-acetyltransferase from Acremonium chrysogenum. | Matsuyama K, Matsumoto H, Matsuda A, Sugiura H, Komatsu K, Ichikawa S | 1992 Sep | 1368946 |