EC number:2.3.1.180
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.180 |
|---|---|
| Description: | Beta-ketoacyl-[acyl-carrier-protein] synthase III. |
| Alternative Name: |
KASIII. KAS III. Beta-ketoacyl-acyl carrier protein synthase III. Beta-ketoacyl-ACP synthase III. Beta-ketoacyl (acyl carrier protein) synthase III. 3-oxoacyl:ACP synthase III. 3-ketoacyl-acyl carrier protein synthase III. |
| Cath: | 1.10.110.40; 1.10.1200.10; 1.10.1470.20; 1.10.287.1960; 1.10.287.3140; 1.20.1050.120; 1.20.5.3540; 3.20.20.70; 3.30.1120.10; 3.30.1120.100; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.180 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.180 |
| KEGG Enzyme Link: | KEGG2.3.1.180 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.180 |
| ExPASy Enzyme Link: | ExPASy2.3.1.180 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.180 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.180 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.180 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.180 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.180 |
EC number:2.3.1.180
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:12080 | acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA |
| RULE(radius=1) | [C:1][S:2][C:3](=[O:4])[*:5].[C:6][S:7][C:8](=[O:9])[C:10][C:11](=[O:12])[O:13]>>[C:1][SH:2].[O+0:13]=[C:11]=[O:12].[C:6][S:7][C:8](=[O:9])[C:10][C:3](=[O:4])[*:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of beta-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis. | Han L, Lobo S, Reynolds KA | 1998 Sep | 9721286 |
| Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis. | Heath RJ, Rock CO | 1996 Nov 1 | 8910376 |
| Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli. | Heath RJ, Rock CO | 1995 Nov 3 | 7592873 |
| Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthases. | Yuan Y, Sachdeva M, Leeds JA, Meredith TC | 2012 Oct | 22753059 |
| Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus. | Qiu X, Choudhry AE, Janson CA, Grooms M, Daines RA, Lonsdale JT, Khandekar SS | 2005 Aug | 15987898 |
| Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH). | Li Y, Florova G, Reynolds KA | 2005 Jun | 15901703 |
| Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12. | Tsay JT, Oh W, Larson TJ, Jackowski S, Rock CO | 1992 Apr 5 | 1551888 |
| Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH). | Khandekar SS, Gentry DR, Van Aller GS, Warren P, Xiang H, Silverman C, Doyle ML, Chambers PA, Konstantinidis AK, Brandt M, Daines RA, Lonsdale JT | 2001 Aug 10 | 11375394 |
| Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis. | Choi KH, Kremer L, Besra GS, Rock CO | 2000 Sep 8 | 10840036 |
| beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis. | Choi KH, Heath RJ, Rock CO | 2000 Jan | 10629181 |