EC number:2.3.1.184
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.184 | ||
|---|---|---|---|
| Description: | Acyl-homoserine-lactone synthase. | ||
| Alternative Name: |
N-acyl homoserine lactone synthase. Autoinducer synthesis protein. Autoinducer synthase. AHSL synthase. AHL synthase. Acylhomoserine lactone synthase. Acyl-homoserinelactone synthase. Acyl-homoserine lactone synthase. Acyl homoserine lactone synthase. | ||
| Prosite: | PDOC51186; | ||
| PDB: |
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| Cath: | 3.40.630.30; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.184 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.184 |
| KEGG Enzyme Link: | KEGG2.3.1.184 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.184 |
| ExPASy Enzyme Link: | ExPASy2.3.1.184 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.184 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.184 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.184 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.184 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.184 |
EC number:2.3.1.184
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:10096 | a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine |
| RULE(radius=1) | [*:1]-[S+;H0:2](-[*:3])-[CH2;+0:4]-[*:5]-[*:6](-[NH2;+0:7])-[*:8]-[OH;+0:9].[*:10]-[S;H0;+0:11]-[C;H0;+0:12](-[*:13])=[*:14]>>[*:13]-[C;H0;+0:12](=[*:14])-[NH;+0:7]-[*:6]1-[*:8]-[O;H0;+0:9]-[CH2;+0:4]-[*:5]-1.[*:1]-[S;H0;+0:2]-[*:3].[*:10]-[SH;+0:11] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein. | Schaefer AL, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP | 1996 Sep 3 | 8790360 |
| Isolation and characterization of an autoinducer synthase from Acinetobacter baumannii. | Niu C, Clemmer KM, Bonomo RA, Rather PN | 2008 May | 18281398 |
| Specificity of acyl-homoserine lactone synthases examined by mass spectrometry. | Gould TA, Herman J, Krank J, Murphy RC, Churchill ME | 2006 Jan | 16385066 |
| Chemical mechanism and substrate specificity of RhlI, an acylhomoserine lactone synthase from Pseudomonas aeruginosa. | Raychaudhuri A, Jerga A, Tipton PA | 2005 Mar 1 | 15723540 |
| Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis. | Ulrich RL | 2004 Oct | 15466564 |
| Structure of the Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI. | Gould TA, Schweizer HP, Churchill ME | 2004 Aug | 15306017 |
| Functional sites and evolutionary connections of acylhomoserine lactone synthases. | Chakrabarti S, Sowdhamini R | 2003 Apr | 12736370 |
| Crystallization and rhenium MAD phasing of the acyl-homoserinelactone synthase EsaI. | Watson WT, Murphy FV 4th, Gould TA, Jambeck P, Val DL, Cronan JE Jr, Beck von Bodman S, Churchill ME | 2001 Dec | 11717525 |
| Acylhomoserine lactone synthase activity of the Vibrio fischeri AinS protein. | Hanzelka BL, Parsek MR, Val DL, Dunlap PV, Cronan JE Jr, Greenberg EP | 1999 Sep | 10482519 |
| Acyl homoserine-lactone quorum-sensing signal generation. | Parsek MR, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP | 1999 Apr 13 | 10200267 |