EC number:2.3.1.189

Enzyme

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EC Tree
     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.189
Description:Mycothiol synthase.
Prosite: PDOC51186;
PDB:
PDBScop
Cath: 3.40.630.30;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.189
BRENDA Enzyme Link: BRENDA 2.3.1.189
KEGG Enzyme Link: KEGG2.3.1.189
BioCyc Enzyme Link: BioCyc 2.3.1.189
ExPASy Enzyme Link: ExPASy2.3.1.189
EC2PDB Enzyme Link: EC2PDB 2.3.1.189
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.189
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.189
IntEnz Enzyme Link: IntEnz 2.3.1.189
MEDLINE Enzyme Link: MEDLINE 2.3.1.189

EC number:2.3.1.189

MSA:

2.3.1.189;
Phylogenetic Tree:

2.3.1.189;
Uniprot:
M-CSA:
RHEA:26172 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The substrate-induced conformational change of Mycobacterium tuberculosis mycothiol synthase.Vetting MW, Yu M, Rendle PM, Blanchard JS2006 Feb 316326705
Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases.Vetting MW, Roderick SL, Yu M, Blanchard JS2003 Sep12930994
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes.Koledin T, Newton GL, Fahey RC2002 Nov12375100