EC number:2.3.1.199

Enzyme

Download
EC Tree
     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.199
Description:Very-long-chain 3-oxoacyl-CoA synthase.
Alternative Name: Very-long-chain beta-ketoacyl-CoA synthase.
Very-long-chain 3-ketoacyl-CoA synthase.
Condensing enzyme.
Cath: 3.10.20.90;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.199
BRENDA Enzyme Link: BRENDA 2.3.1.199
KEGG Enzyme Link: KEGG2.3.1.199
BioCyc Enzyme Link: BioCyc 2.3.1.199
ExPASy Enzyme Link: ExPASy2.3.1.199
EC2PDB Enzyme Link: EC2PDB 2.3.1.199
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.199
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.199
IntEnz Enzyme Link: IntEnz 2.3.1.199
MEDLINE Enzyme Link: MEDLINE 2.3.1.199

EC number:2.3.1.199

MSA:

2.3.1.199;
Phylogenetic Tree:

2.3.1.199;
Uniprot:
M-CSA:
RHEA:32727 a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA
RULE(radius=1) [C:1][S:2][C:3](=[O:4])[*:5].[C:6][S:7][C:8](=[O:9])[C:10][C:11](=[O:12])[O:13]>>[C:1][SH:2].[O+0:13]=[C:11]=[O:12].[C:6][S:7][C:8](=[O:9])[C:10][C:3](=[O:4])[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Fatty acid elongation in yeast--biochemical characteristics of the enzyme system and isolation of elongation-defective mutants.Dittrich F, Zajonc D, Hühne K, Hoja U, Ekici A, Greiner E, Klein H, Hofmann J, Bessoule JJ, Sperling P, Schweizer E1998 Mar 159546663
ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation.Oh CS, Toke DA, Mandala S, Martin CE1997 Jul 119211877
Inhibition of saturated very-long-chain fatty acid biosynthesis by mefluidide and perfluidone, selective inhibitors of 3-ketoacyl-CoA synthases.Tresch S, Heilmann M, Christiansen N, Looser R, Grossmann K2012 Apr22284369
ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice.Zadravec D, Tvrdik P, Guillou H, Haslam R, Kobayashi T, Napier JA, Capecchi MR, Jacobsson A2011 Feb21106902
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A2010 Oct 2620937905
The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy.Ofman R, Dijkstra IM, van Roermund CW, Burger N, Turkenburg M, van Cruchten A, van Engen CE, Wanders RJ, Kemp S2010 Mar20166112
Mammalian fatty acid elongases.Jump DB200919763486
A molecular caliper mechanism for determining very long-chain fatty acid length.Denic V, Weissman JS2007 Aug 2417719544
Substrate specificity of Arabidopsis 3-ketoacyl-CoA synthases.Blacklock BJ, Jaworski JG2006 Jul 2816765910
Identification and expression of mammalian long-chain PUFA elongation enzymes.Leonard AE, Kelder B, Bobik EG, Chuang LT, Lewis CJ, Kopchick JJ, Mukerji P, Huang YS2002 Aug12371743
Engineering and mechanistic studies of the Arabidopsis FAE1 beta-ketoacyl-CoA synthase, FAE1 KCS.Ghanevati M, Jaworski JG2002 Jul12135493
CUT1, an Arabidopsis gene required for cuticular wax biosynthesis and pollen fertility, encodes a very-long-chain fatty acid condensing enzyme.Millar AA, Clemens S, Zachgo S, Giblin EM, Taylor DC, Kunst L1999 May10330468