Enzyme

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     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.206
Description:3,5,7-trioxododecanoyl-CoA synthase.
Alternative Name: Olivetol synthase.

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.206
BRENDA Enzyme Link: BRENDA 2.3.1.206
KEGG Enzyme Link: KEGG2.3.1.206
BioCyc Enzyme Link: BioCyc 2.3.1.206
ExPASy Enzyme Link: ExPASy2.3.1.206
EC2PDB Enzyme Link: EC2PDB 2.3.1.206
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.206
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.206
IntEnz Enzyme Link: IntEnz 2.3.1.206
MEDLINE Enzyme Link: MEDLINE 2.3.1.206
MSA:

2.3.1.206;

Phylogenetic Tree:

2.3.1.206;

Uniprot:
M-CSA:
RHEA:34119 3 H(+) + hexanoyl-CoA + 3 malonyl-CoA = 3,5,7-trioxododecanoyl-CoA + 3 CO2 + 3 CoA
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3]-[CH2;+0:4]-[CH3;+0:5].[*:6]=[C;H0;+0:7](-[OH;+0:8])-[CH2;+0:9]-[C;H0;+0:10](=[*:11])-[S;H0;+0:12]-[*:13].[*:14]=[C;H0;+0:15](-[OH;+0:16])-[CH2;+0:17]-[C;H0;+0:18](=[O;H0;+0:19])-[S;H0;+0:20]-[*:21].[*:22]=[C;H0;+0:23](-[OH;+0:24])-[CH2;+0:25]-[C;H0;+0:26](=[O;H0;+0:27])-[S;H0;+0:28]-[*:29].[H+;H0:30].[H+;H0:31].[H+;H0:32]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:19])-[*:3]-[C;H0;+0:4](=[O;H0;+0:27])-[CH2;+0:5]-[C;H0;+0:10](=[*:11])-[CH2;+0:9]-[CH2;+0:17]-[CH2;+0:18]-[CH2;+0:25]-[CH3;+0:26].[*:13]-[SH;+0:12].[*:21]-[SH;+0:20].[*:29]-[SH;+0:28].[*:6]=[C;H0;+0:7]=[O;H0;+0:8].[*:14]=[C;H0;+0:15]=[O;H0;+0:16].[*:22]=[C;H0;+0:23]=[O;H0;+0:24]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE2012 Jul 3122802619
Identification of candidate genes affecting Delta9-tetrahydrocannabinol biosynthesis in Cannabis sativa.Marks MD, Tian L, Wenger JP, Omburo SN, Soto-Fuentes W, He J, Gang DR, Weiblen GD, Dixon RA200919581347
Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway.Taura F, Tanaka S, Taguchi C, Fukamizu T, Tanaka H, Shoyama Y, Morimoto S2009 Jun 1819454282