EC number:2.3.1.21
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.21 | ||
|---|---|---|---|
| Description: | Carnitine O-palmitoyltransferase. | ||
| Prosite: | PDOC00402; | ||
| PDB: |
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| Cath: | 1.10.275.20; 1.20.1280.180; 1.20.5.3450; 3.30.559.10; 3.30.559.40; 3.30.559.70; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.21 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.21 |
| KEGG Enzyme Link: | KEGG2.3.1.21 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.21 |
| ExPASy Enzyme Link: | ExPASy2.3.1.21 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.21 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.21 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.21 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.21 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.21 |
| RHEA:12661 | (R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)-carnitine |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular basis of hepatic carnitine palmitoyltransferase I deficiency. | IJlst L, Mandel H, Oostheim W, Ruiter JP, Gutman A, Wanders RJ | 1998 Aug 1 | 9691089 |
| Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I. | Zhu H, Shi J, de Vries Y, Arvidson DN, Cregg JM, Woldegiorgis G | 1997 Nov 1 | 9344464 |
| Functional analysis of iPSC-derived myocytes from a patient with carnitine palmitoyltransferase II deficiency. | Yasuno T, Osafune K, Sakurai H, Asaka I, Tanaka A, Yamaguchi S, Yamada K, Hitomi H, Arai S, Kurose Y, Higaki Y, Sudo M, Ando S, Nakashima H, Saito T, Kaneoka H | 2014 May 30 | 24780397 |
| Carnitine palmitoyltransferase 2: New insights on the substrate specificity and implications for acylcarnitine profiling. | Violante S, Ijlst L, van Lenthe H, de Almeida IT, Wanders RJ, Ventura FV | 2010 Sep | 20538056 |
| The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity. | Borthwick K, Jackson VN, Price NT, Zammit VA | 2006 Nov 3 | 16908527 |
| Molecular and enzymatic characterization of a unique carnitine palmitoyltransferase 1A mutation in the Hutterite community. | Prip-Buus C, Thuillier L, Abadi N, Prasad C, Dilling L, Klasing J, Demaugre F, Greenberg CR, Haworth JC, Droin V, Kadhom N, Gobin S, Kamoun P, Girard J, Bonnefont JP | 2001 May | 11350182 |