EC number:2.3.1.231

Enzyme

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     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.231
Description:methoxycarbonyltransferase.
Alternative Name: tRNA-yW synthesizing enzyme-4.
Cath: 2.120.10.80; 3.40.50.150;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.231
BRENDA Enzyme Link: BRENDA 2.3.1.231
KEGG Enzyme Link: KEGG2.3.1.231
BioCyc Enzyme Link: BioCyc 2.3.1.231
ExPASy Enzyme Link: ExPASy2.3.1.231
EC2PDB Enzyme Link: EC2PDB 2.3.1.231
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.231
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.231
IntEnz Enzyme Link: IntEnz 2.3.1.231
MEDLINE Enzyme Link: MEDLINE 2.3.1.231

EC number:2.3.1.231

MSA:

2.3.1.231;
Phylogenetic Tree:

2.3.1.231;
Uniprot:
M-CSA:
RHEA:37119 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]-[S+;H0:4](-[*:5])-[CH3;+0:6].[*:7]=[C;H0;+0:8]=[O;H0;+0:9]>>[*:1]-[NH;+0:2]-[C;H0;+0:8](=[*:7])-[O;H0;+0:9]-[CH3;+0:6].[*:3]-[S;H0;+0:4]-[*:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.Kato M, Araiso Y, Noma A, Nagao A, Suzuki T, Ishitani R, Nureki O2011 Mar20972222
Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.Suzuki Y, Noma A, Suzuki T, Ishitani R, Nureki O2009 May19287006
Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.Noma A, Kirino Y, Ikeuchi Y, Suzuki T2006 May 1716642040