EC number:2.3.1.238
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.238 |
|---|---|
| Description: | Monacolin J acid methylbutanoate transferase. |
| Cath: | 3.40.710.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.238 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.238 |
| KEGG Enzyme Link: | KEGG2.3.1.238 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.238 |
| ExPASy Enzyme Link: | ExPASy2.3.1.238 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.238 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.238 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.238 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.238 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.238 |
EC number:2.3.1.238
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:43064 | (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + monacolin J carboxylate = holo-[2-methylbutanoate polyketide synthase] + lovastatin carboxylate |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]-[S;H0;+0:4]-[C;H0;+0:5](=[*:6])-[*:7]>>[*:3]-[SH;+0:4].[*:6]=[C;H0;+0:5](-[*:7])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. | Kennedy J, Auclair K, Kendrew SG, Park C, Vederas JC, Hutchinson CR | 1999 May 21 | 10334994 |
| Directed evolution and structural characterization of a simvastatin synthase. | Gao X, Xie X, Pashkov I, Sawaya MR, Laidman J, Zhang W, Cacho R, Yeates TO, Tang Y | 2009 Oct 30 | 19875080 |
| Acyltransferase mediated polyketide release from a fungal megasynthase. | Xie X, Meehan MJ, Xu W, Dorrestein PC, Tang Y | 2009 Jun 24 | 19530726 |
| Rational improvement of simvastatin synthase solubility in Escherichia coli leads to higher whole-cell biocatalytic activity. | Xie X, Pashkov I, Gao X, Guerrero JL, Yeates TO, Tang Y | 2009 Jan 1 | 18988191 |
| Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. | Xie X, Watanabe K, Wojcicki WA, Wang CC, Tang Y | 2006 Nov | 17113998 |