EC number:2.3.1.245

Enzyme

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EC Tree
     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.245
Description:3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase.
Cath: 3.20.20.70;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.245
BRENDA Enzyme Link: BRENDA 2.3.1.245
KEGG Enzyme Link: KEGG2.3.1.245
BioCyc Enzyme Link: BioCyc 2.3.1.245
ExPASy Enzyme Link: ExPASy2.3.1.245
EC2PDB Enzyme Link: EC2PDB 2.3.1.245
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.245
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.245
IntEnz Enzyme Link: IntEnz 2.3.1.245
MEDLINE Enzyme Link: MEDLINE 2.3.1.245

EC number:2.3.1.245

MSA:

2.3.1.245;
Phylogenetic Tree:

2.3.1.245;
Uniprot:
M-CSA:
RHEA:44736 acetyl-CoA + dihydroxyacetone phosphate = 3-hydroxy-2,4-pentanedione 5-phosphate + CoA
RULE(radius=1) [*:1]-[CH2;+0:2]-[*:3].[*:4]=[C;H0;+0:5](-[*:6])-[S;H0;+0:7]-[*:8]>>[*:8]-[SH;+0:7].[*:4]=[C;H0;+0:5](-[*:6])-[CH;+0:2](-[*:1])-[*:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2.Marques JC, Oh IK, Ly DC, Lamosa P, Ventura MR, Miller ST, Xavier KB2014 Sep 3025225400
Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein.Marques JC, Lamosa P, Russell C, Ventura R, Maycock C, Semmelhack MF, Miller ST, Xavier KB2011 May 2021454635
The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF.Diaz Z, Xavier KB, Miller ST2009 Aug 2819714241