EC number:2.3.1.246
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.246 |
|---|---|
| Description: | 3,5-dihydroxyphenylacetyl-CoA synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.246 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.246 |
| KEGG Enzyme Link: | KEGG2.3.1.246 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.246 |
| ExPASy Enzyme Link: | ExPASy2.3.1.246 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.246 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.246 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.246 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.246 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.246 |
EC number:2.3.1.246
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:44744 | 4 H(+) + 4 malonyl-CoA = (3,5-dihydroxyphenyl)acetyl-CoA + 4 CO2 + 3 CoA + H2O |
| RULE(radius=1) | [C:0][S;H0:1][C:2](=[O:3])[C:4][C:29](=[O:30])[O:31].[C:5][S;H0:6][C:7](=[O:8])[C:9][C:10](=[O:11])[O:12].[C:13][S;H0:14][C:15](=[O:16])[C:17][C:18](=[O:19])[O:20].[C:21][S;H0:22][C:23](=[O:24])[C:25][C:26](=[O:27])[O:28]>>[C:0][S:1][C:2](=[O:3])[C:4][c:23]1[c:25][c:7]([OH:8])[c:9][c:15]([OH:16])[c:17]1.[O:11]=[C:10]=[O:12].[O:19]=[C:18]=[O:20].[O:27]=[C:26]=[O:28].[O:30]=[C:29]=[O:31].[C:5][SH:6].[C:13][SH:14].[C:21][SH:22].[OH2:24] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Chain elongation and cyclization in type III PKS DpgA. | Wu HC, Li YS, Liu YC, Lyu SY, Wu CJ, Li TL | 2012 Apr 16 | 22492619 |
| Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. | Tseng CC, McLoughlin SM, Kelleher NL, Walsh CT | 2004 Feb 3 | 14744141 |
| Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine. | Chen H, Tseng CC, Hubbard BK, Walsh CT | 2001 Dec 18 | 11752437 |
| A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine. | Pfeifer V, Nicholson GJ, Ries J, Recktenwald J, Schefer AB, Shawky RM, Schröder J, Wohlleben W, Pelzer S | 2001 Oct 19 | 11495926 |