EC number:2.3.1.250

Enzyme

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EC Tree
     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.250
Description:[Wnt protein] O-palmitoleoyl transferase.
Alternative Name: Porcupine.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.250
BRENDA Enzyme Link: BRENDA 2.3.1.250
KEGG Enzyme Link: KEGG2.3.1.250
BioCyc Enzyme Link: BioCyc 2.3.1.250
ExPASy Enzyme Link: ExPASy2.3.1.250
EC2PDB Enzyme Link: EC2PDB 2.3.1.250
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.250
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.250
IntEnz Enzyme Link: IntEnz 2.3.1.250
MEDLINE Enzyme Link: MEDLINE 2.3.1.250

EC number:2.3.1.250

MSA:

2.3.1.250;
Phylogenetic Tree:

2.3.1.250;
Uniprot:
M-CSA:
RHEA:45336 (9Z)-hexadecenoyl-CoA + [Wnt protein]-L-serine = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA
RULE(radius=1) [*:1]-[OH;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[O;H0;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Identification of the WNT1 residues required for palmitoylation by Porcupine.Miranda M, Galli LM, Enriquez M, Szabo LA, Gao X, Hannoush RN, Burrus LW2014 Dec 2025451226
Identification of key residues and regions important for porcupine-mediated Wnt acylation.Rios-Esteves J, Haugen B, Resh MD2014 Jun 1324798332
Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine.Gao X, Hannoush RN2014 Jan24292069
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion.Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, Kondoh H, Takao T, Takada S2006 Dec17141155