EC number:2.3.1.254
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.254 |
|---|---|
| Description: | N-terminal methionine N(alpha)-acetyltransferase NatB. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.254 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.254 |
| KEGG Enzyme Link: | KEGG2.3.1.254 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.254 |
| ExPASy Enzyme Link: | ExPASy2.3.1.254 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.254 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.254 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.254 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.254 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.254 |
EC number:2.3.1.254
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:50480 | acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. | Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X | 2015 May | 25966763 |
| Synthetic lethal screen of NAA20, a catalytic subunit gene of NatB N-terminal acetylase in Saccharomyces cerevisiae. | Lee KE, Ahn JY, Kim JM, Hwang CS | 2014 Oct | 25163837 |
| Mutation of an Arabidopsis NatB N-alpha-terminal acetylation complex component causes pleiotropic developmental defects. | Ferrández-Ayela A, Micol-Ponce R, Sánchez-García AB, Alonso-Peral MM, Micol JL, Ponce MR | 2013 | 24244708 |
| Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. | Starheim KK, Arnesen T, Gromyko D, Ryningen A, Varhaug JE, Lillehaug JR | 2008 Oct 15 | 18570629 |
| Identification and specificities of N-terminal acetyltransferases from Saccharomyces cerevisiae. | Polevoda B, Norbeck J, Takakura H, Blomberg A, Sherman F | 1999 Nov 1 | 10545125 |
| RHEA:50484 | acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. | Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X | 2015 May | 25966763 |
| Synthetic lethal screen of NAA20, a catalytic subunit gene of NatB N-terminal acetylase in Saccharomyces cerevisiae. | Lee KE, Ahn JY, Kim JM, Hwang CS | 2014 Oct | 25163837 |
| Mutation of an Arabidopsis NatB N-alpha-terminal acetylation complex component causes pleiotropic developmental defects. | Ferrández-Ayela A, Micol-Ponce R, Sánchez-García AB, Alonso-Peral MM, Micol JL, Ponce MR | 2013 | 24244708 |
| Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. | Starheim KK, Arnesen T, Gromyko D, Ryningen A, Varhaug JE, Lillehaug JR | 2008 Oct 15 | 18570629 |
| Identification and specificities of N-terminal acetyltransferases from Saccharomyces cerevisiae. | Polevoda B, Norbeck J, Takakura H, Blomberg A, Sherman F | 1999 Nov 1 | 10545125 |
| RHEA:50488 | acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. | Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X | 2015 May | 25966763 |
| Synthetic lethal screen of NAA20, a catalytic subunit gene of NatB N-terminal acetylase in Saccharomyces cerevisiae. | Lee KE, Ahn JY, Kim JM, Hwang CS | 2014 Oct | 25163837 |
| Mutation of an Arabidopsis NatB N-alpha-terminal acetylation complex component causes pleiotropic developmental defects. | Ferrández-Ayela A, Micol-Ponce R, Sánchez-García AB, Alonso-Peral MM, Micol JL, Ponce MR | 2013 | 24244708 |
| Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. | Starheim KK, Arnesen T, Gromyko D, Ryningen A, Varhaug JE, Lillehaug JR | 2008 Oct 15 | 18570629 |
| Identification and specificities of N-terminal acetyltransferases from Saccharomyces cerevisiae. | Polevoda B, Norbeck J, Takakura H, Blomberg A, Sherman F | 1999 Nov 1 | 10545125 |
| RHEA:50492 | acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. | Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X | 2015 May | 25966763 |
| Synthetic lethal screen of NAA20, a catalytic subunit gene of NatB N-terminal acetylase in Saccharomyces cerevisiae. | Lee KE, Ahn JY, Kim JM, Hwang CS | 2014 Oct | 25163837 |
| Mutation of an Arabidopsis NatB N-alpha-terminal acetylation complex component causes pleiotropic developmental defects. | Ferrández-Ayela A, Micol-Ponce R, Sánchez-García AB, Alonso-Peral MM, Micol JL, Ponce MR | 2013 | 24244708 |
| Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. | Starheim KK, Arnesen T, Gromyko D, Ryningen A, Varhaug JE, Lillehaug JR | 2008 Oct 15 | 18570629 |
| Identification and specificities of N-terminal acetyltransferases from Saccharomyces cerevisiae. | Polevoda B, Norbeck J, Takakura H, Blomberg A, Sherman F | 1999 Nov 1 | 10545125 |