EC number:2.3.1.255
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.255 |
|---|---|
| Description: | N-terminal amino-acid N(alpha)-acetyltransferase NatA. |
| Cath: | 3.40.630.30; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.255 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.255 |
| KEGG Enzyme Link: | KEGG2.3.1.255 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.255 |
| ExPASy Enzyme Link: | ExPASy2.3.1.255 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.255 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.255 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.255 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.255 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.255 |
EC number:2.3.1.255
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:50496 | acetyl-CoA + N-terminal glycyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetylglycyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| The biological functions of Naa10 - From amino-terminal acetylation to human disease. | Dörfel MJ, Lyon GJ | 2015 Aug 10 | 25987439 |
| Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. | Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X | 2015 May | 25966763 |
| Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. | Mullen JR, Kayne PS, Moerschell RP, Tsunasawa S, Gribskov M, Colavito-Shepanski M, Grunstein M, Sherman F, Sternglanz R | 1989 Jul | 2551674 |
| ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. | Park EC, Szostak JW | 1992 Jun | 1600941 |
| Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. | Arnesen T, Anderson D, Baldersheim C, Lanotte M, Varhaug JE, Lillehaug JR | 2005 Mar 15 | 15496142 |
| The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. | Gautschi M, Just S, Mun A, Ross S, Rücknagel P, Dubaquié Y, Ehrenhofer-Murray A, Rospert S | 2003 Oct | 14517307 |
| An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. | Sugiura N, Adams SM, Corriveau RA | 2003 Oct 10 | 12888564 |
| RHEA:50500 | acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| The biological functions of Naa10 - From amino-terminal acetylation to human disease. | Dörfel MJ, Lyon GJ | 2015 Aug 10 | 25987439 |
| Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. | Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X | 2015 May | 25966763 |
| Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. | Mullen JR, Kayne PS, Moerschell RP, Tsunasawa S, Gribskov M, Colavito-Shepanski M, Grunstein M, Sherman F, Sternglanz R | 1989 Jul | 2551674 |
| ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. | Park EC, Szostak JW | 1992 Jun | 1600941 |
| Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. | Arnesen T, Anderson D, Baldersheim C, Lanotte M, Varhaug JE, Lillehaug JR | 2005 Mar 15 | 15496142 |
| The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. | Gautschi M, Just S, Mun A, Ross S, Rücknagel P, Dubaquié Y, Ehrenhofer-Murray A, Rospert S | 2003 Oct | 14517307 |
| An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. | Sugiura N, Adams SM, Corriveau RA | 2003 Oct 10 | 12888564 |
| RHEA:50504 | acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-seryl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| The biological functions of Naa10 - From amino-terminal acetylation to human disease. | Dörfel MJ, Lyon GJ | 2015 Aug 10 | 25987439 |
| Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. | Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X | 2015 May | 25966763 |
| Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. | Mullen JR, Kayne PS, Moerschell RP, Tsunasawa S, Gribskov M, Colavito-Shepanski M, Grunstein M, Sherman F, Sternglanz R | 1989 Jul | 2551674 |
| ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. | Park EC, Szostak JW | 1992 Jun | 1600941 |
| Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. | Arnesen T, Anderson D, Baldersheim C, Lanotte M, Varhaug JE, Lillehaug JR | 2005 Mar 15 | 15496142 |
| The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. | Gautschi M, Just S, Mun A, Ross S, Rücknagel P, Dubaquié Y, Ehrenhofer-Murray A, Rospert S | 2003 Oct | 14517307 |
| An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. | Sugiura N, Adams SM, Corriveau RA | 2003 Oct 10 | 12888564 |
| RHEA:50508 | acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-valyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| The biological functions of Naa10 - From amino-terminal acetylation to human disease. | Dörfel MJ, Lyon GJ | 2015 Aug 10 | 25987439 |
| Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. | Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X | 2015 May | 25966763 |
| Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. | Mullen JR, Kayne PS, Moerschell RP, Tsunasawa S, Gribskov M, Colavito-Shepanski M, Grunstein M, Sherman F, Sternglanz R | 1989 Jul | 2551674 |
| ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. | Park EC, Szostak JW | 1992 Jun | 1600941 |
| Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. | Arnesen T, Anderson D, Baldersheim C, Lanotte M, Varhaug JE, Lillehaug JR | 2005 Mar 15 | 15496142 |
| The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. | Gautschi M, Just S, Mun A, Ross S, Rücknagel P, Dubaquié Y, Ehrenhofer-Murray A, Rospert S | 2003 Oct | 14517307 |
| An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. | Sugiura N, Adams SM, Corriveau RA | 2003 Oct 10 | 12888564 |
| RHEA:50512 | acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| The biological functions of Naa10 - From amino-terminal acetylation to human disease. | Dörfel MJ, Lyon GJ | 2015 Aug 10 | 25987439 |
| Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. | Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X | 2015 May | 25966763 |
| Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. | Mullen JR, Kayne PS, Moerschell RP, Tsunasawa S, Gribskov M, Colavito-Shepanski M, Grunstein M, Sherman F, Sternglanz R | 1989 Jul | 2551674 |
| ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. | Park EC, Szostak JW | 1992 Jun | 1600941 |
| Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. | Arnesen T, Anderson D, Baldersheim C, Lanotte M, Varhaug JE, Lillehaug JR | 2005 Mar 15 | 15496142 |
| The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. | Gautschi M, Just S, Mun A, Ross S, Rücknagel P, Dubaquié Y, Ehrenhofer-Murray A, Rospert S | 2003 Oct | 14517307 |
| An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. | Sugiura N, Adams SM, Corriveau RA | 2003 Oct 10 | 12888564 |
| RHEA:50516 | acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-threonyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| The biological functions of Naa10 - From amino-terminal acetylation to human disease. | Dörfel MJ, Lyon GJ | 2015 Aug 10 | 25987439 |
| Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. | Xu F, Huang Y, Li L, Gannon P, Linster E, Huber M, Kapos P, Bienvenut W, Polevoda B, Meinnel T, Hell R, Giglione C, Zhang Y, Wirtz M, Chen S, Li X | 2015 May | 25966763 |
| Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. | Mullen JR, Kayne PS, Moerschell RP, Tsunasawa S, Gribskov M, Colavito-Shepanski M, Grunstein M, Sherman F, Sternglanz R | 1989 Jul | 2551674 |
| ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. | Park EC, Szostak JW | 1992 Jun | 1600941 |
| Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. | Arnesen T, Anderson D, Baldersheim C, Lanotte M, Varhaug JE, Lillehaug JR | 2005 Mar 15 | 15496142 |
| The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. | Gautschi M, Just S, Mun A, Ross S, Rücknagel P, Dubaquié Y, Ehrenhofer-Murray A, Rospert S | 2003 Oct | 14517307 |
| An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. | Sugiura N, Adams SM, Corriveau RA | 2003 Oct 10 | 12888564 |