EC number:2.3.1.258
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.258 |
|---|---|
| Description: | N-terminal methionine N(alpha)-acetyltransferase NatE. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.258 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.258 |
| KEGG Enzyme Link: | KEGG2.3.1.258 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.258 |
| ExPASy Enzyme Link: | ExPASy2.3.1.258 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.258 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.258 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.258 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.258 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.258 |
EC number:2.3.1.258
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:50520 | acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. | Starheim KK, Gromyko D, Evjenth R, Ryningen A, Varhaug JE, Lillehaug JR, Arnesen T | 2009 Jul | 19398576 |
| Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. | Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA, Weiser-Evans MC | 2006 Mar 31 | 16484612 |
| Cytoplasmic N-terminal protein acetylation is required for efficient photosynthesis in Arabidopsis. | Pesaresi P, Gardner NA, Masiero S, Dietzmann A, Eichacker L, Wickner R, Salamini F, Leister D | 2003 Aug | 12897255 |
| Composition and function of the eukaryotic N-terminal acetyltransferase subunits. | Polevoda B, Sherman F | 2003 Aug 15 | 12890471 |
| NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. | Polevoda B, Sherman F | 2001 Jun 8 | 11274203 |
| RHEA:50528 | acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. | Starheim KK, Gromyko D, Evjenth R, Ryningen A, Varhaug JE, Lillehaug JR, Arnesen T | 2009 Jul | 19398576 |
| Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. | Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA, Weiser-Evans MC | 2006 Mar 31 | 16484612 |
| Cytoplasmic N-terminal protein acetylation is required for efficient photosynthesis in Arabidopsis. | Pesaresi P, Gardner NA, Masiero S, Dietzmann A, Eichacker L, Wickner R, Salamini F, Leister D | 2003 Aug | 12897255 |
| Composition and function of the eukaryotic N-terminal acetyltransferase subunits. | Polevoda B, Sherman F | 2003 Aug 15 | 12890471 |
| NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. | Polevoda B, Sherman F | 2001 Jun 8 | 11274203 |
| RHEA:50532 | acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. | Starheim KK, Gromyko D, Evjenth R, Ryningen A, Varhaug JE, Lillehaug JR, Arnesen T | 2009 Jul | 19398576 |
| Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. | Wenzlau JM, Garl PJ, Simpson P, Stenmark KR, West J, Artinger KB, Nemenoff RA, Weiser-Evans MC | 2006 Mar 31 | 16484612 |
| Cytoplasmic N-terminal protein acetylation is required for efficient photosynthesis in Arabidopsis. | Pesaresi P, Gardner NA, Masiero S, Dietzmann A, Eichacker L, Wickner R, Salamini F, Leister D | 2003 Aug | 12897255 |
| Composition and function of the eukaryotic N-terminal acetyltransferase subunits. | Polevoda B, Sherman F | 2003 Aug 15 | 12890471 |
| NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. | Polevoda B, Sherman F | 2001 Jun 8 | 11274203 |
| RHEA:50564 | acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases. | Van Damme P, Hole K, Gevaert K, Arnesen T | 2015 Jul | 25886145 |
| Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity. | Evjenth R, Hole K, Karlsen OA, Ziegler M, Arnesen T, Lillehaug JR | 2009 Nov 6 | 19744929 |
| Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. | Pimenta-Marques A, Tostões R, Marty T, Barbosa V, Lehmann R, Martinho RG | 2008 Nov 15 | 18801358 |
| The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner. | Hou F, Chu CW, Kong X, Yokomori K, Zou H | 2007 May 21 | 17502424 |
| RHEA:50568 | acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases. | Van Damme P, Hole K, Gevaert K, Arnesen T | 2015 Jul | 25886145 |
| Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity. | Evjenth R, Hole K, Karlsen OA, Ziegler M, Arnesen T, Lillehaug JR | 2009 Nov 6 | 19744929 |
| Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. | Pimenta-Marques A, Tostões R, Marty T, Barbosa V, Lehmann R, Martinho RG | 2008 Nov 15 | 18801358 |
| The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner. | Hou F, Chu CW, Kong X, Yokomori K, Zou H | 2007 May 21 | 17502424 |
| RHEA:50572 | acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases. | Van Damme P, Hole K, Gevaert K, Arnesen T | 2015 Jul | 25886145 |
| Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity. | Evjenth R, Hole K, Karlsen OA, Ziegler M, Arnesen T, Lillehaug JR | 2009 Nov 6 | 19744929 |
| Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. | Pimenta-Marques A, Tostões R, Marty T, Barbosa V, Lehmann R, Martinho RG | 2008 Nov 15 | 18801358 |
| The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner. | Hou F, Chu CW, Kong X, Yokomori K, Zou H | 2007 May 21 | 17502424 |
| RHEA:50576 | acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases. | Van Damme P, Hole K, Gevaert K, Arnesen T | 2015 Jul | 25886145 |
| Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity. | Evjenth R, Hole K, Karlsen OA, Ziegler M, Arnesen T, Lillehaug JR | 2009 Nov 6 | 19744929 |
| Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. | Pimenta-Marques A, Tostões R, Marty T, Barbosa V, Lehmann R, Martinho RG | 2008 Nov 15 | 18801358 |
| The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner. | Hou F, Chu CW, Kong X, Yokomori K, Zou H | 2007 May 21 | 17502424 |
| RHEA:50580 | acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosis. | Pathak D, Bhat AH, Sapehia V, Rai J, Rao A | 2016 Jun 29 | 27353550 |
| N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases. | Van Damme P, Hole K, Gevaert K, Arnesen T | 2015 Jul | 25886145 |
| Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity. | Evjenth R, Hole K, Karlsen OA, Ziegler M, Arnesen T, Lillehaug JR | 2009 Nov 6 | 19744929 |
| Differential requirements of a mitotic acetyltransferase in somatic and germ line cells. | Pimenta-Marques A, Tostões R, Marty T, Barbosa V, Lehmann R, Martinho RG | 2008 Nov 15 | 18801358 |
| The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner. | Hou F, Chu CW, Kong X, Yokomori K, Zou H | 2007 May 21 | 17502424 |