EC number:2.3.1.259

Enzyme

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EC Tree
     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.259
Description:N-terminal methionine N(alpha)-acetyltransferase NatF.
Cath: 3.40.630.30;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.259
BRENDA Enzyme Link: BRENDA 2.3.1.259
KEGG Enzyme Link: KEGG2.3.1.259
BioCyc Enzyme Link: BioCyc 2.3.1.259
ExPASy Enzyme Link: ExPASy2.3.1.259
EC2PDB Enzyme Link: EC2PDB 2.3.1.259
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.259
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.259
IntEnz Enzyme Link: IntEnz 2.3.1.259
MEDLINE Enzyme Link: MEDLINE 2.3.1.259

EC number:2.3.1.259

MSA:

2.3.1.259;
Phylogenetic Tree:

2.3.1.259;
Uniprot:
M-CSA:
RHEA:50604 acetyl-CoA + N-terminal L-methionyl-[transmembrane protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein]
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation.Van Damme P, Hole K, Pimenta-Marques A, Helsens K, Vandekerckhove J, Martinho RG, Gevaert K, Arnesen T2011 Jul21750686
An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.Aksnes H, Van Damme P, Goris M, Starheim KK, Marie M, Støve SI, Hoel C, Kalvik TV, Hole K, Glomnes N, Furnes C, Ljostveit S, Ziegler M, Niere M, Gevaert K, Arnesen T2015 Mar 325732826