EC number:2.3.1.39
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.39 |
|---|---|
| Description: | [Acyl-carrier-protein] S-malonyltransferase. |
| Alternative Name: |
MCAT. Malonyl-CoA/dephospho-CoA acyltransferase. Malonyl-CoA-acyl carrier protein transacylase. Malonyl transferase. Malonyl transacylase. Malonyl coenzyme A-acyl carrier protein transacylase. Acyl carrier protein malonyltransferase. |
| Cath: | 1.10.110.40; 1.10.1200.10; 1.10.1470.20; 1.10.287.1960; 1.10.287.3140; 1.10.287.3150; 1.20.1050.120; 1.20.5.3540; 1.20.5.3640; 3.20.20.70; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.39 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.39 |
| KEGG Enzyme Link: | KEGG2.3.1.39 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.39 |
| ExPASy Enzyme Link: | ExPASy2.3.1.39 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.39 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.39 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.39 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.39 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.39 |
| RHEA:41792 | holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP] |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[S;H0;+0:4]-[*:5].[*:6]-[SH;+0:7]>>[*:1]-[C;H0;+0:2](=[*:3])-[S;H0;+0:7]-[*:6].[*:5]-[SH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis. | Heath RJ, Rock CO | 1996 Nov 1 | 8910376 |
| Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli. | Heath RJ, Rock CO | 1995 Nov 3 | 7592873 |
| Human fatty acid synthase: properties and molecular cloning. | Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ | 1995 Sep 12 | 7567999 |
| Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase subunit protein reconstitutes enzyme activity. | Jayakumar A, Chirala SS, Wakil SJ | 1997 Nov 11 | 9356448 |
| Cloning and expression of the multifunctional human fatty acid synthase and its subdomains in Escherichia coli. | Jayakumar A, Huang WY, Raetz B, Chirala SS, Wakil SJ | 1996 Dec 10 | 8962082 |
| The isolation of the two subunits of yeast fatty acid synthetase. | Stoops JK, Wakil SJ | 1978 Sep 14 | 365179 |
| Cloning, nucleotide sequence, and expression of the Escherichia coli fabD gene, encoding malonyl coenzyme A-acyl carrier protein transacylase. | Verwoert II, Verbree EC, van der Linden KH, Nijkamp HJ, Stuitje AR | 1992 May | 1314802 |
| Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. | Zhang L, Joshi AK, Smith S | 2003 Oct 10 | 12882974 |
| Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis. | Kremer L, Dover LG, Carrère S, Nampoothiri KM, Lesjean S, Brown AK, Brennan PJ, Minnikin DE, Locht C, Besra GS | 2002 Jun 1 | 12023885 |
| Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II. | Kremer L, Nampoothiri KM, Lesjean S, Dover LG, Graham S, Betts J, Brennan PJ, Minnikin DE, Locht C, Besra GS | 2001 Jul 27 | 11373295 |