EC number:2.3.1.41

Enzyme

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EC Tree
     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.41
Description:Beta-ketoacyl-[acyl-carrier-protein] synthase I.
Alternative Name: KAS I.
Fatty acid condensing enzyme.
Condensing enzyme.
Beta-ketoacylsynthase.
Beta-ketoacyl-acyl carrier protein synthetase.
Beta-ketoacyl-ACP synthetase.
Beta-ketoacyl-ACP synthase I.
Beta-ketoacyl-[acyl carrier protein] synthase.
Beta-ketoacyl synthetase.
Beta-ketoacyl acyl carrier protein synthase.
Acyl-malonyl(acyl-carrier-protein)-condensing enzyme.
Acyl-malonyl acyl carrier protein-condensing enzyme.
3-oxoacyl-[acyl-carrier-protein] synthase.
3-ketoacyl-acyl carrier protein synthase.
Prosite: PDOC00529;
PDB:
PDBScop
2CDH 8057091; 8057092; 8057091; 8057092; 8025058; 8025061; 8037437; 8037440; 8025058; 8025061; 8037437; 8037440; 8057091; 8057092; 8025058; 8025061; 8037437; 8037440;
4NA1 8045100; 8055886; 8055887; 8055888; 8045100; 8055886; 8055887; 8055888;
5BP1 8045099; 8055889; 8055890; 8055891; 8055892; 8055893; 8055894; 8055895;
2HG4 8045098; 8051502; 8055901; 8055902; 8055903; 8055904; 8055905; 8055906; 8055907; 8055908; 8045098; 8051502; 8055901; 8055902; 8055903; 8055904; 8055905; 8055906; 8055907; 8055908; 8045098; 8051502; 8055901; 8055902; 8055903; 8055904; 8055905; 8055906; 8055907; 8055908; 8045098; 8051502; 8055901; 8055902; 8055903; 8055904; 8055905; 8055906; 8055907; 8055908; 8045098; 8051502; 8055901; 8055902; 8055903; 8055904; 8055905; 8055906; 8055907; 8055908; 8045098; 8051502; 8055901; 8055902; 8055903; 8055904; 8055905; 8055906; 8055907; 8055908;
2QO3 8045094; 8055827; 8055828; 8055829; 8055830; 8055831; 8055832; 8055834; 8045094; 8055827; 8055828; 8055829; 8055830; 8055831; 8055832; 8055834;
 » show all
Cath: 1.10.110.40; 1.10.1200.10; 1.10.1470.20; 1.10.287.1960; 1.10.287.3140; 1.10.287.3150; 1.20.1050.120; 1.20.5.3540; 1.20.5.3640; 3.20.20.70;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.41
BRENDA Enzyme Link: BRENDA 2.3.1.41
KEGG Enzyme Link: KEGG2.3.1.41
BioCyc Enzyme Link: BioCyc 2.3.1.41
ExPASy Enzyme Link: ExPASy2.3.1.41
EC2PDB Enzyme Link: EC2PDB 2.3.1.41
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.41
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.41
IntEnz Enzyme Link: IntEnz 2.3.1.41
MEDLINE Enzyme Link: MEDLINE 2.3.1.41

EC number:2.3.1.41

MSA:

2.3.1.41;
Phylogenetic Tree:

2.3.1.41;
Uniprot:
M-CSA:
RHEA:22836 a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:4].[*:5]-[S;H0;+0:6]-[C;H0;+0:7](=[*:8])-[*;H0;+0:9].[H+;H0:10]>>[*:1]-[C;H0;+0:2](=[*:3])-[*;H0;+0:9].[*:5]-[SH;+0:6].[*:8]=[C;H0;+0:7]=[O;H0;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli.Garwin JL, Klages AL, Cronan JE Jr1980 Dec 257002930
Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from Escherichia coli.Toomey RE, Wakil SJ1966 Mar 105327099
Multiple forms of beta-ketoacyl-acyl carrier protein synthetase in Escherichia coli.D'Agnolo G, Rosenfeld IS, Vagelos PR1975 Jul 25237914
Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain.Zhang L, Joshi AK, Hofmann J, Schweizer E, Smith S2005 Apr 115668256