EC number:2.3.1.47

Enzyme

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EC Tree
     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.47
Description:8-amino-7-oxononanoate synthase.
Alternative Name: AONS.
8-amino-7-ketopelargonate synthase.
7-keto-8-aminopelargonic acid synthetase.
7-KAP synthetase.
Prosite: PDOC00518;
PDB:
PDBScop
Cath: 3.40.640.10; 3.90.1150.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.47
BRENDA Enzyme Link: BRENDA 2.3.1.47
KEGG Enzyme Link: KEGG2.3.1.47
BioCyc Enzyme Link: BioCyc 2.3.1.47
ExPASy Enzyme Link: ExPASy2.3.1.47
EC2PDB Enzyme Link: EC2PDB 2.3.1.47
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.47
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.47
IntEnz Enzyme Link: IntEnz 2.3.1.47
MEDLINE Enzyme Link: MEDLINE 2.3.1.47

EC number:2.3.1.47

MSA:

2.3.1.47;
Phylogenetic Tree:

2.3.1.47;
Uniprot:
M-CSA:
RHEA:42288 H(+) + L-alanine + pimeloyl-[ACP] = 8-amino-7-oxononanoate + CO2 + holo-[ACP]
RULE(radius=1) [*:1]=[C;H0;+0:2](-[*:3])-[S;H0;+0:4]-[*:5].[*:6]=[C;H0;+0:7](-[OH;+0:8])-[CH;+0:9](-[*:10])-[*:11].[H+;H0:12]>>[*:5]-[SH;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[CH;+0:9](-[*:10])-[*:11].[*:6]=[C;H0;+0:7]=[O;H0;+0:8]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Biotin synthesis begins by hijacking the fatty acid synthetic pathway.Lin S, Hanson RE, Cronan JE2010 Sep20693992
Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies.Webster SP, Alexeev D, Campopiano DJ, Watt RM, Alexeeva M, Sawyer L, Baxter RL2000 Jan 2510642176