Enzyme

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     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.48
Description:Histone acetyltransferase.
Alternative Name: Protein lysine acetyltransferase.
Lysine acetyltransferase.
Cath: 1.10.10.10; 1.10.10.390; 1.10.12.10; 1.10.150.60; 1.10.1630.10; 1.10.20.10; 1.10.246.20; 1.10.287.10; 1.10.287.1070; 1.10.287.1740;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.48
BRENDA Enzyme Link: BRENDA 2.3.1.48
KEGG Enzyme Link: KEGG2.3.1.48
BioCyc Enzyme Link: BioCyc 2.3.1.48
ExPASy Enzyme Link: ExPASy2.3.1.48
EC2PDB Enzyme Link: EC2PDB 2.3.1.48
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.48
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.48
IntEnz Enzyme Link: IntEnz 2.3.1.48
MEDLINE Enzyme Link: MEDLINE 2.3.1.48
MSA:

2.3.1.48;

Phylogenetic Tree:

2.3.1.48;

Uniprot:
M-CSA:
RHEA:45948 acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Spotlight on protein N-terminal acetylation.Ree R, Varland S, Arnesen T2018 Jul 2730054468
Identification of Novel Protein Lysine Acetyltransferases in Escherichia coli.Christensen DG, Meyer JG, Baumgartner JT, D'Souza AK, Nelson WC, Payne SH, Kuhn ML, Schilling B, Wolfe AJ2018 Oct 2330352934
Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7.Kim KH, An DR, Song J, Yoon JY, Kim HS, Yoon HJ, Im HN, Kim J, Kim DJ, Lee SJ, Kim KH, Lee HM, Kim HJ, Jo EK, Lee JY, Suh SW2012 May 1522547814
Biochemical and thermodynamic analyses of Salmonella enterica Pat, a multidomain, multimeric N(ε)-lysine acetyltransferase involved in carbon and energy metabolism.Thao S, Escalante-Semerena JC201122010215
Histone acetyltransferase complexes: one size doesn't fit all.Lee KK, Workman JL2007 Apr17380162
Identification of the protein acetyltransferase (Pat) enzyme that acetylates acetyl-CoA synthetase in Salmonella enterica.Starai VJ, Escalante-Semerena JC2004 Jul 2315236963

RHEA:21992 acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone]
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.Verreault A, Kaufman PD, Kobayashi R, Stillman B1998 Jan 159427644
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM1997 Aug 89267036
The transcriptional coactivators p300 and CBP are histone acetyltransferases.Ogryzko VV, Schiltz RL, Russanova V, Howard BH, Nakatani Y1996 Nov 298945521
An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.Aksnes H, Van Damme P, Goris M, Starheim KK, Marie M, Støve SI, Hoel C, Kalvik TV, Hole K, Glomnes N, Furnes C, Ljostveit S, Ziegler M, Niere M, Gevaert K, Arnesen T2015 Mar 325732826
Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.Das C, Roy S, Namjoshi S, Malarkey CS, Jones DN, Kutateladze TG, Churchill ME, Tyler JK2014 Mar 2524616510
Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.Delvecchio M, Gaucher J, Aguilar-Gurrieri C, Ortega E, Panne D2013 Sep23934153
Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer.Tropberger P, Pott S, Keller C, Kamieniarz-Gdula K, Caron M, Richter F, Li G, Mittler G, Liu ET, Bühler M, Margueron R, Schneider R2013 Feb 1423415232
Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1.Wu H, Moshkina N, Min J, Zeng H, Joshua J, Zhou MM, Plotnikov AN2012 Jun 522615379
Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex.Huang J, Wan B, Wu L, Yang Y, Dou Y, Lei M2012 Jun22547026
MYST protein acetyltransferase activity requires active site lysine autoacetylation.Yuan H, Rossetto D, Mellert H, Dang W, Srinivasan M, Johnson J, Hodawadekar S, Ding EC, Speicher K, Abshiru N, Perry R, Wu J, Yang C, Zheng YG, Speicher DW, Thibault P, Verreault A, Johnson FB, Berger SL, Sternglanz R, McMahon SB, Côté J, Marmorstein R2012 Jan 422020126
Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1.Kadlec J, Hallacli E, Lipp M, Holz H, Sanchez-Weatherby J, Cusack S, Akhtar A2011 Feb21217699
Catalytic-site mutations in the MYST family histone Acetyltransferase Esa1.Decker PV, Yu DY, Iizuka M, Qiu Q, Smith MM2008 Mar18245364
The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting.Holbert MA, Sikorski T, Carten J, Snowflack D, Hodawadekar S, Marmorstein R2007 Dec 1417925393
Catalytic mechanism of a MYST family histone acetyltransferase.Berndsen CE, Albaugh BN, Tan S, Denu JM2007 Jan 2317223684
Circadian regulator CLOCK is a histone acetyltransferase.Doi M, Hirayama J, Sassone-Corsi P2006 May 516678094
Tip60 acetyltransferase activity is controlled by phosphorylation.Lemercier C, Legube G, Caron C, Louwagie M, Garin J, Trouche D, Khochbin S2003 Feb 1412468530
The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate.Yan Y, Harper S, Speicher DW, Marmorstein R2002 Nov12368900
Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein.Kitabayashi I, Aikawa Y, Nguyen LA, Yokoyama A, Ohki M2001 Dec 1711742995
Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase.Makowski AM, Dutnall RN, Annunziato AT2001 Nov 2311585814
The monocytic leukemia zinc finger protein MOZ is a histone acetyltransferase.Champagne N, Pelletier N, Yang XJ2001 Jan 1811313971
The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition.Akhtar A, Becker PB2001 Feb11258702
ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.Kawasaki H, Schiltz L, Chiu R, Itakura K, Taira K, Nakatani Y, Yokoyama KK2000 May 1110821277
A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF.Neal KC, Pannuti A, Smith ER, Lucchesi JC2000 Jan 3110786633
Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein.Champagne N, Bertos NR, Pelletier N, Wang AH, Vezmar M, Yang Y, Heng HH, Yang XJ1999 Oct 110497217
Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein.Iizuka M, Stillman B1999 Aug 1310438470
Tip60 acetylates six lysines of a specific class in core histones in vitro.Kimura A, Horikoshi M1998 Dec10096020