EC number:2.3.1.5
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.5 |
|---|---|
| Description: | Arylamine N-acetyltransferase. |
| Alternative Name: |
Arylamine acetylase. |
| Cath: | 3.30.2140.10; 3.30.2140.20; 3.40.630.30; 2.40.128.150; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.5 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.5 |
| KEGG Enzyme Link: | KEGG2.3.1.5 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.5 |
| ExPASy Enzyme Link: | ExPASy2.3.1.5 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.5 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.5 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.5 |
| RHEA:16613 | acetyl-CoA + an arylamine = an N-acetylarylamine + CoA |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: increased expression results in isoniazid resistance. | Payton M, Auty R, Delgoda R, Everett M, Sim E | 1999 Feb | 9973365 |
| Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis. | Lack NA, Kawamura A, Fullam E, Laurieri N, Beard S, Russell AJ, Evangelopoulos D, Westwood I, Sim E | 2009 Mar 1 | 19014350 |
| Kinetic and chemical mechanism of arylamine N-acetyltransferase from Mycobacterium tuberculosis. | Sikora AL, Frankel BA, Blanchard JS | 2008 Oct 7 | 18795795 |
| The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid. | Sandy J, Mushtaq A, Kawamura A, Sinclair J, Sim E, Noble M | 2002 May 10 | 12054803 |