Enzyme

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     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.50
Description:Serine C-palmitoyltransferase.
Prosite: PDOC00518;
PDB:
PDBScop
Cath: 1.10.1200.10; 3.40.640.10; 3.90.1150.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.50
BRENDA Enzyme Link: BRENDA 2.3.1.50
KEGG Enzyme Link: KEGG2.3.1.50
BioCyc Enzyme Link: BioCyc 2.3.1.50
ExPASy Enzyme Link: ExPASy2.3.1.50
EC2PDB Enzyme Link: EC2PDB 2.3.1.50
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.50
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.50
IntEnz Enzyme Link: IntEnz 2.3.1.50
MEDLINE Enzyme Link: MEDLINE 2.3.1.50
MSA:

2.3.1.50;

Phylogenetic Tree:

2.3.1.50;

Uniprot:
M-CSA:
RHEA:14761 H(+) + hexadecanoyl-CoA + L-serine = 3-oxosphinganine + CO2 + CoA
RULE(radius=1) [*:1]=[C;H0;+0:2](-[*:3])-[S;H0;+0:4]-[*:5].[*:6]=[C;H0;+0:7](-[OH;+0:8])-[CH;+0:9](-[*:10])-[*:11].[H+;H0:12]>>[*:5]-[SH;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[CH;+0:9](-[*:10])-[*:11].[*:6]=[C;H0;+0:7]=[O;H0;+0:8]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis.Nagiec MM, Baltisberger JA, Wells GB, Lester RL, Dickson RC1994 Aug 168058731
Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities.Han G, Gupta SD, Gable K, Niranjanakumari S, Moitra P, Eichler F, Brown RH Jr, Harmon JM, Dunn TM2009 May 1919416851
The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics.Raman MC, Johnson KA, Yard BA, Lowther J, Carter LG, Naismith JH, Campopiano DJ2009 Jun 1919376777
Bacterial serine palmitoyltransferase: a water-soluble homodimeric prototype of the eukaryotic enzyme.Ikushiro H, Hayashi H, Kagamiyama H2003 Apr 1112686119
Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses.Perry DK2002 Dec 3012531548
Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase.Gable K, Han G, Monaghan E, Bacikova D, Natarajan M, Williams R, Dunn TM2002 Mar 2211781309
A water-soluble homodimeric serine palmitoyltransferase from Sphingomonas paucimobilis EY2395T strain. Purification, characterization, cloning, and overproduction.Ikushiro H, Hayashi H, Kagamiyama H2001 May 2511279212