EC number:2.3.1.54
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.54 | ||
|---|---|---|---|
| Description: | Formate C-acetyltransferase. | ||
| Alternative Name: |
Pyruvate formate-lyase. | ||
| Prosite: | PDOC00665; | ||
| PDB: |
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| Cath: | 3.20.20.70; 3.20.70.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.54 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.54 |
| KEGG Enzyme Link: | KEGG2.3.1.54 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.54 |
| ExPASy Enzyme Link: | ExPASy2.3.1.54 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.54 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.54 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.54 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.54 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.54 |
| RHEA:11844 | acetyl-CoA + formate = CoA + pyruvate |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[S;H0;+0:4]-[*:5].[*:6]=[CH;+0:7]-[*:8]>>[*:5]-[SH;+0:4].[*:1]=[C;H0;+0:2](-[*:3])-[C;H0;+0:7](=[*:6])-[*:8] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Pyruvate formate-lyase of Escherichia coli: the acetyl-enzyme intermediate. | Knappe J, Blaschkowski HP, Gröbner P, Schmitt T | 1974 Dec 16 | 4615902 |
| Modification of Cys-418 of pyruvate formate-lyase by methacrylic acid, based on its radical mechanism. | Plaga W, Vielhaber G, Wallach J, Knappe J | 2000 Jan 21 | 10648809 |
| Pyruvate formate lyase is structurally homologous to type I ribonucleotide reductase. | Leppänen VM, Merckel MC, Ollis DL, Wong KK, Kozarich JW, Goldman A | 1999 Jul 15 | 10425676 |