EC number:2.3.1.57
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.57 |
|---|---|
| Description: | Diamine N-acetyltransferase. |
| Alternative Name: |
Spermidine N(1)-acetyltransferase. Spermidine acetyltransferase. Putrescine N-acetyltransferase. Putrescine acetyltransferase. Putrescine acetylase. Putrescine (diamine)-acetylating enzyme. Diamine acetyltransferase. Acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase. |
| Cath: | 1.10.287.90; 1.10.287.900; 3.40.630.30; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.57 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.57 |
| KEGG Enzyme Link: | KEGG2.3.1.57 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.57 |
| ExPASy Enzyme Link: | ExPASy2.3.1.57 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.57 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.57 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.57 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.57 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.57 |
| RHEA:11116 | acetyl-CoA + an alkane-alpha,omega-diamine = an N-acetylalkane-alpha,omega-diamine + CoA + H(+) |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Properties and structure of spermidine acetyltransferase in Escherichia coli. | Fukuchi J, Kashiwagi K, Takio K, Igarashi K | 1994 Sep 9 | 8077207 |
| Purification and characterization of spermidine/spermine N1-acetyltransferase from rat liver. | Ragione FD, Pegg AE | 1982 Nov 23 | 7150547 |
| Occurrence and induction of spermidine-N1-acetyltransferase in Escherichia coli. | Matsui I, Kamei M, Otani S, Morisawa S, Pegg AE | 1982 Jun 30 | 7052085 |
| The crystal structure of spermidine/spermine N1-acetyltransferase in complex with spermine provides insights into substrate binding and catalysis. | Montemayor EJ, Hoffman DW | 2008 Sep 2 | 18690703 |
| Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. | Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS | 2007 Jun 19 | 17516632 |
| Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme. | Yarlett N, Wu G, Waters WR, Harp JA, Wannemuehler MJ, Morada M, Athanasopoulos D, Martinez MP, Upton SJ, Marton LJ, Frydman BJ | 2007 Apr | 17289169 |
| Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. | Bewley MC, Graziano V, Jiang J, Matz E, Studier FW, Pegg AE, Coleman CS, Flanagan JM | 2006 Feb 14 | 16455797 |
| Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase. | Forouhar F, Lee IS, Vujcic J, Vujcic S, Shen J, Vorobiev SM, Xiao R, Acton TB, Montelione GT, Porter CW, Tong L | 2005 Dec 2 | 16210326 |
| RHEA:25181 | acetyl-CoA + putrescine = CoA + H(+) + N-acetylputrescine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
| RHEA:28150 | acetyl-CoA + spermidine = CoA + H(+) + N(1)-acetylspermidine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Properties and structure of spermidine acetyltransferase in Escherichia coli. | Fukuchi J, Kashiwagi K, Takio K, Igarashi K | 1994 Sep 9 | 8077207 |
| Occurrence and induction of spermidine-N1-acetyltransferase in Escherichia coli. | Matsui I, Kamei M, Otani S, Morisawa S, Pegg AE | 1982 Jun 30 | 7052085 |
| The crystal structure of spermidine/spermine N1-acetyltransferase in complex with spermine provides insights into substrate binding and catalysis. | Montemayor EJ, Hoffman DW | 2008 Sep 2 | 18690703 |
| Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. | Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS | 2007 Jun 19 | 17516632 |
| Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme. | Yarlett N, Wu G, Waters WR, Harp JA, Wannemuehler MJ, Morada M, Athanasopoulos D, Martinez MP, Upton SJ, Marton LJ, Frydman BJ | 2007 Apr | 17289169 |
| Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. | Bewley MC, Graziano V, Jiang J, Matz E, Studier FW, Pegg AE, Coleman CS, Flanagan JM | 2006 Feb 14 | 16455797 |
| Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase. | Forouhar F, Lee IS, Vujcic J, Vujcic S, Shen J, Vorobiev SM, Xiao R, Acton TB, Montelione GT, Porter CW, Tong L | 2005 Dec 2 | 16210326 |
| Characterization of a novel spermidine/spermine acetyltransferase, BltD, from Bacillus subtilis. | Woolridge DP, Martinez JD, Stringer DE, Gerner EW | 1999 Jun 15 | 10359661 |
| RHEA:28270 | acetyl-CoA + spermidine = CoA + H(+) + N(8)-acetylspermidine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Properties and structure of spermidine acetyltransferase in Escherichia coli. | Fukuchi J, Kashiwagi K, Takio K, Igarashi K | 1994 Sep 9 | 8077207 |
| Characterization of a novel spermidine/spermine acetyltransferase, BltD, from Bacillus subtilis. | Woolridge DP, Martinez JD, Stringer DE, Gerner EW | 1999 Jun 15 | 10359661 |
| P/CAF-mediated spermidine acetylation regulates histone acetyltransferase activity. | Burgio G, Corona DF, Nicotra CM, Carruba G, Taibi G | 2016 | 27389534 |
| RHEA:33099 | acetyl-CoA + spermine = CoA + H(+) + N(1)-acetylspermine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The crystal structure of spermidine/spermine N1-acetyltransferase in complex with spermine provides insights into substrate binding and catalysis. | Montemayor EJ, Hoffman DW | 2008 Sep 2 | 18690703 |
| Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. | Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS | 2007 Jun 19 | 17516632 |
| Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme. | Yarlett N, Wu G, Waters WR, Harp JA, Wannemuehler MJ, Morada M, Athanasopoulos D, Martinez MP, Upton SJ, Marton LJ, Frydman BJ | 2007 Apr | 17289169 |
| Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. | Bewley MC, Graziano V, Jiang J, Matz E, Studier FW, Pegg AE, Coleman CS, Flanagan JM | 2006 Feb 14 | 16455797 |
| Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase. | Forouhar F, Lee IS, Vujcic J, Vujcic S, Shen J, Vorobiev SM, Xiao R, Acton TB, Montelione GT, Porter CW, Tong L | 2005 Dec 2 | 16210326 |
| Characterization of a novel spermidine/spermine acetyltransferase, BltD, from Bacillus subtilis. | Woolridge DP, Martinez JD, Stringer DE, Gerner EW | 1999 Jun 15 | 10359661 |