EC number:2.3.1.60
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.60 |
|---|---|
| Description: | Gentamicin 3-N-acetyltransferase. |
| Alternative Name: |
Gentamycin acetyltransferase I. Aminoglycoside acetyltransferase AAC(3)-1. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.60 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.60 |
| KEGG Enzyme Link: | KEGG2.3.1.60 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.60 |
| ExPASy Enzyme Link: | ExPASy2.3.1.60 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.60 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.60 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.60 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.60 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.60 |
| RHEA:14441 | acetyl-CoA + gentamicin C = CoA + H(+) + N(3)-acetylgentamycin C |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate. | Biddlecome S, Haas M, Davies J, Miller GH, Rane DF, Daniels PJ | 1976 Jun | 820250 |
| Purification and properties of gentamicin acetyltransferase I. | Williams JW, Northrop DB | 1976 Jan 13 | 764855 |
| Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa. | Angelatou F, Litsas SB, Kontomichalou P | 1982 Feb | 6281224 |