EC number:2.3.1.61

Enzyme

Download
EC Tree
     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.61
Description:Dihydrolipoyllysine-residue succinyltransferase.
Alternative Name: Succinyl-CoA:dihydrolipoate S-succinyltransferase.
Succinyl-CoA:dihydrolipoamide S-succinyltransferase.
Lipoyl transsuccinylase.
Lipoic transsuccinylase.
Lipoate succinyltransferase.
Dihydrolipoyl transsuccinylase.
Dihydrolipolyl transsuccinylase.
Dihydrolipoic transsuccinylase.
Dihydrolipoamide succinyltransferase.
Dihydrolipoamide S-succinyltransferase.
Cath: 1.10.287.1150; 3.30.559.10; 4.10.320.10; 3.40.50.970; 2.40.50.100; 3.40.50.11610; 3.40.50.12470;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.61
BRENDA Enzyme Link: BRENDA 2.3.1.61
KEGG Enzyme Link: KEGG2.3.1.61
BioCyc Enzyme Link: BioCyc 2.3.1.61
ExPASy Enzyme Link: ExPASy2.3.1.61
EC2PDB Enzyme Link: EC2PDB 2.3.1.61
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.61
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.61
IntEnz Enzyme Link: IntEnz 2.3.1.61
MEDLINE Enzyme Link: MEDLINE 2.3.1.61

EC number:2.3.1.61

MSA:

2.3.1.61;
Phylogenetic Tree:

2.3.1.61;
Uniprot:
M-CSA:
RHEA:15213 (R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA
RULE(radius=1) [*:1]-[C;H0;+0:2](=[*:3])-[S;H0;+0:4]-[*:5].[*:6]-[SH;+0:7]>>[*:1]-[C;H0;+0:2](=[*:3])-[S;H0;+0:7]-[*:6].[*:5]-[SH;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Crystal structure of the truncated cubic core component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex.Knapp JE, Mitchell DT, Yazdi MA, Ernst SR, Reed LJ, Hackert ML1998 Jul 249677295
The E2 domain of OdhA of Corynebacterium glutamicum has succinyltransferase activity dependent on lipoyl residues of the acetyltransferase AceF.Hoffelder M, Raasch K, van Ooyen J, Eggeling L2010 Oct20675489
Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism.Wagner T, Bellinzoni M, Wehenkel A, O'Hare HM, Alzari PM2011 Aug 2621867916
Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.Perham RN200010966480