EC number:2.3.1.67
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.67 |
|---|---|
| Description: | 1-alkylglycerophosphocholine O-acetyltransferase. |
| Alternative Name: |
Platelet-activating factor-synthesizing enzyme. Platelet-activating factor acylhydrolase. PAF acetyltransferase. LysoPAF:acetyl CoA acetyltransferase. Lyso-platelet-activating factor:acetyl-CoA acetyltransferase. Lyso-platelet activating factor:acetyl-CoA acetyltransferase. Lyso-GPC:acetyl CoA acetyltransferase. Blood platelet-activating factor acetyltransferase. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase. Acetyl-CoA:lyso-PAF acetyltransferase. acetyltransferase. Acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O- 1-alkyl-2-lysolecithin acetyltransferase. 1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.67 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.67 |
| KEGG Enzyme Link: | KEGG2.3.1.67 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.67 |
| ExPASy Enzyme Link: | ExPASy2.3.1.67 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.67 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.67 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.67 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.67 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.67 |
| RHEA:18461 | 1-O-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA |
| RULE(radius=1) | [*:1]-[OH;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[O;H0;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid. | Wykle RL, Malone B, Snyder F | 1980 Nov 10 | 7430122 |
| Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine. | Moessinger C, Kuerschner L, Spandl J, Shevchenko A, Thiele C | 2011 Jun 17 | 21498505 |
| Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers. | Agarwal AK, Garg A | 2010 Aug | 20363836 |
| Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2. | Cao J, Shan D, Revett T, Li D, Wu L, Liu W, Tobin JF, Gimeno RE | 2008 Jul 4 | 18458083 |
| Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes. | Soupene E, Fyrst H, Kuypers FA | 2008 Jan 8 | 18156367 |
| A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. | Shindou H, Hishikawa D, Nakanishi H, Harayama T, Ishii S, Taguchi R, Shimizu T | 2007 Mar 2 | 17182612 |
| Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production. | Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T | 2006 Jul 21 | 16704971 |