EC number:2.3.1.74
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.74 | ||
|---|---|---|---|
| Description: | Chalcone synthase. | ||
| Alternative Name: |
Naringenin-chalcone synthase. Flavonone synthase. 6'-deoxychalcone synthase. | ||
| Prosite: | PDOC00403; | ||
| PDB: |
|
||
| Cath: | 3.40.47.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.74 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.74 |
| KEGG Enzyme Link: | KEGG2.3.1.74 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.74 |
| ExPASy Enzyme Link: | ExPASy2.3.1.74 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.74 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.74 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.74 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.74 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.74 |
| RHEA:11128 | 4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA |
| RULE(radius=1) | [C:0][S;H0:1][C:2](=[O:3])[*:4].[C:5][S;H0:6][C:7](=[O:8])[C:9][C:10](=[O:11])[O:12].[C:13][S;H0:14][C:15](=[O:16])[C:17][C:18](=[O:19])[O:20].[C:21][S;H0:22][C:23](=[O:24])[C:25][C:26](=[O:27])[O:28]>>[OH:24][c:23]1[c:25][c:7]([OH:8])[c:9][c:15]([OH:16])[c:17]1[C:2](=[O:3])[*:4].[O:11]=[C:10]=[O:12].[O:19]=[C:18]=[O:20].[O:27]=[C:26]=[O:28].[C:5][SH:6].[C:13][SH:14].[C:21][SH:22].[C:0][SH:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Highly purified "flavanone synthase" from parsley catalyzes the formation of naringenin chalcone. | Heller W, Hahlbrock K | 1980 Apr 1 | 7436427 |
| NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract. | Ayabe S, Udagawa A, Furuya T | 1988 Mar | 3355160 |
| Characterization of three chalcone synthase-like genes from apple (Malus x domestica Borkh.). | Yahyaa M, Ali S, Davidovich-Rikanati R, Ibdah M, Shachtier A, Eyal Y, Lewinsohn E, Ibdah M | 2017 Aug | 28482241 |
| Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. | Jez JM, Bowman ME, Noel JP | 2002 Apr 16 | 11959984 |
| Structure-guided programming of polyketide chain-length determination in chalcone synthase. | Jez JM, Bowman ME, Noel JP | 2001 Dec 11 | 11732902 |
| Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. | Jez JM, Ferrer JL, Bowman ME, Dixon RA, Noel JP | 2000 Feb 8 | 10653632 |