EC number:2.3.1.81

Enzyme

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     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.81
Description:Aminoglycoside N(3)-acetyltransferase.
Alternative Name: Aminoglycoside 3-N-acetyltransferase.
3-aminoglycoside acetyltransferase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.81
BRENDA Enzyme Link: BRENDA 2.3.1.81
KEGG Enzyme Link: KEGG2.3.1.81
BioCyc Enzyme Link: BioCyc 2.3.1.81
ExPASy Enzyme Link: ExPASy2.3.1.81
EC2PDB Enzyme Link: EC2PDB 2.3.1.81
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.81
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.81
IntEnz Enzyme Link: IntEnz 2.3.1.81
MEDLINE Enzyme Link: MEDLINE 2.3.1.81

EC number:2.3.1.81

MSA:

2.3.1.81;
Phylogenetic Tree:

2.3.1.81;
Uniprot:
M-CSA:
RHEA:12665 a 2-deoxystreptamine antibiotic + acetyl-CoA = a N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin.Davies J, O'Connor S1978 Jul356726