EC number:2.3.1.87
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
| ID: | 2.3.1.87 |
|---|---|
| Description: | Aralkylamine N-acetyltransferase. |
| Alternative Name: |
Serotonin N-acetyltransferase. Serotonin acetyltransferase. Serotonin acetylase. Melatonin rhythm enzyme. Arylalkylamine N-acetyltransferase. AANAT. |
| Cath: | 3.40.630.30; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.87 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.87 |
| KEGG Enzyme Link: | KEGG2.3.1.87 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.87 |
| ExPASy Enzyme Link: | ExPASy2.3.1.87 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.87 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.87 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.87 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.87 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.87 |
| RHEA:25217 | acetyl-CoA + serotonin = CoA + H(+) + N-acetylserotonin |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Substrate specificity and inhibition studies of human serotonin N-acetyltransferase. | Ferry G, Loynel A, Kucharczyk N, Bertin S, Rodriguez M, Delagrange P, Galizzi JP, Jacoby E, Volland JP, Lesieur D, Renard P, Canet E, Fauchère JL, Boutin JA | 2000 Mar 24 | 10722724 |
| The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. | Coon SL, Mazuruk K, Bernard M, Roseboom PH, Klein DC, Rodriguez IR | 1996 May 15 | 8661026 |
| Identification of an arylalkylamine N-acyltransferase from Drosophila melanogaster that catalyzes the formation of long-chain N-acylserotonins. | Dempsey DR, Jeffries KA, Anderson RL, Carpenter AM, Rodriquez Opsina S, Merkler DJ | 2014 Feb 14 | 24444601 |
| Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 A resolution suggests a catalytic mechanism. | Hickman AB, Klein DC, Dyda F | 1999 Jan | 10024876 |
| RHEA:20497 | 2-arylethylamine + acetyl-CoA = CoA + H(+) + N-acetyl-2-arylethylamine |
| RULE(radius=1) | [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Indoleamine analogs as probes of the substrate selectivity and catalytic mechanism of serotonin N-acetyltransferase. | Khalil EM, De Angelis J, Cole PA | 1998 Nov 13 | 9804794 |
| Molecular and biochemical characterization of the aaNAT1 (Dat) locus in Drosophila melanogaster: differential expression of two gene products. | Brodbeck D, Amherd R, Callaerts P, Hintermann E, Meyer UA, Affolter M | 1998 Jul | 9703021 |
| Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87). | De Angelis J, Gastel J, Klein DC, Cole PA | 1998 Jan 30 | 9446620 |
| Cloning of an arylalkylamine N-acetyltransferase (aaNAT1) from Drosophila melanogaster expressed in the nervous system and the gut. | Hintermann E, Grieder NC, Amherd R, Brodbeck D, Meyer UA | 1996 Oct 29 | 8901578 |
| Isolation and characterization of an arylalkylamine N-acetyltransferase from Drosophila melanogaster. | Hintermann E, Jenö P, Meyer UA | 1995 Nov 13 | 7498465 |
| Functional diversity of Teleost arylalkylamine N-acetyltransferase-2: is the timezyme evolution driven by habitat temperature? | Cazaméa-Catalan D, Magnanou E, Helland R, Vanegas G, Besseau L, Boeuf G, Paulin CH, Jørgensen EH, Falcón J | 2012 Oct | 22998157 |
| Investigation of the roles of catalytic residues in serotonin N-acetyltransferase. | Scheibner KA, De Angelis J, Burley SK, Cole PA | 2002 May 17 | 11884405 |
| cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation. | Coon SL, Weller JL, Korf HW, Namboodiri MA, Rollag M, Klein DC | 2001 Jun 29 | 11313340 |
| Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from Drosophila melanogaster. | Amherd R, Hintermann E, Walz D, Affolter M, Meyer UA | 2000 Nov | 11098219 |
| Substrate specificity and inhibition studies of human serotonin N-acetyltransferase. | Ferry G, Loynel A, Kucharczyk N, Bertin S, Rodriguez M, Delagrange P, Galizzi JP, Jacoby E, Volland JP, Lesieur D, Renard P, Canet E, Fauchère JL, Boutin JA | 2000 Mar 24 | 10722724 |