EC number:2.3.1.9
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.1 Transferring groups other than aminoacyl groups |
3D structure
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2WL6;
2WL5;
2WL4;
2WKV;
2WKU;
2WKT;
2VU2;
2VU1;
2VU0;
2VTZ;
1QFL;
1OU6;
1NL7;
1M4T;
1M4S;
1M3Z;
1M3K;
1M1T;
1M1O;
1DM3;
1DLV;
1DLU;
2D3T;
1WDM;
1WDL;
1AFW;
1WDK;
6DV2;
5ZRV;
5ZQZ;
5XZ5;
5XYJ;
5ONC;
5LP7;
5F38;
5F0V;
4XL2;
4WYS;
4WYR;
4W61;
4UBW;
4UBV;
4UBU;
4UBT;
4O9C;
4O9A;
4O99;
4NZS;
4DD5;
4C2K;
4C2J;
4B3J;
4B3I;
4B3H;
3GOA;
2WU9;
2IIK;
2IBY;
2IBW;
2IBU;
2IB9;
2IB8;
2IB7;
2F2S;
2C7Z;
2C7Y;
1WL5;
1WL4;
1PXT;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.1.9 |
| BRENDA Enzyme Link: | BRENDA 2.3.1.9 |
| KEGG Enzyme Link: | KEGG2.3.1.9 |
| BioCyc Enzyme Link: | BioCyc 2.3.1.9 |
| ExPASy Enzyme Link: | ExPASy2.3.1.9 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.1.9 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.1.9 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.1.9 |
| IntEnz Enzyme Link: | IntEnz 2.3.1.9 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.1.9 |
| RHEA:21036 | 2 acetyl-CoA = acetoacetyl-CoA + CoA |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:2]-[*:1] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates. | Antonenkov VD, Van Veldhoven PP, Waelkens E, Mannaerts GP | 1997 Oct 10 | 9325339 |
| Comparison of the stability and substrate specificity of purified peroxisomal 3-oxoacyl-CoA thiolases A and B from rat liver. | Antonenkov VD, Van Veldhoven PP, Waelkens E, Mannaerts GP | 1999 Feb 25 | 10064897 |
| Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase. | Song XQ, Fukao T, Yamaguchi S, Miyazawa S, Hashimoto T, Orii T | 1994 May 30 | 7911016 |
| The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities. | Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK | 2014 Dec 1 | 25478839 |
| Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function. | Haapalainen AM, Meriläinen G, Pirilä PL, Kondo N, Fukao T, Wierenga RK | 2007 Apr 10 | 17371050 |