EC number:2.3.1.97

Enzyme

Download
EC Tree
     2. Transferases
        2.3 Acyltransferases
            2.3.1 Transferring groups other than aminoacyl groups
ID:2.3.1.97
Description:Glycylpeptide N-tetradecanoyltransferase.
Alternative Name: Peptide N-tetradecanoyltransferase.
Peptide N-myristoyltransferase.
Prosite: PDOC00752;
PDB:
PDBScop
1IYL 8030226; 8030227; 8042605; 8042606; 8030226; 8030227; 8042605; 8042606; 8030226; 8030227; 8042605; 8042606; 8030226; 8030227; 8042605; 8042606;
1NMT 8030226; 8030227; 8042605; 8042606; 8030226; 8030227; 8042605; 8042606; 8030226; 8030227; 8042605; 8042606;
1IYK 8030226; 8030227; 8042605; 8042606; 8030226; 8030227; 8042605; 8042606;
2P6G 8021590; 8021592; 8033970; 8033972; 8021590; 8021592; 8033970; 8033972; 8021590; 8021592; 8033970; 8033972; 8021590; 8021592; 8033970; 8033972; 8021590; 8021592; 8033970; 8033972; 8021590; 8021592; 8033970; 8033972;
2P6F 8021590; 8021592; 8033970; 8033972; 8021590; 8021592; 8033970; 8033972; 8021590; 8021592; 8033970; 8033972; 8021590; 8021592; 8033970; 8033972; 8021590; 8021592; 8033970; 8033972; 8021590; 8021592; 8033970; 8033972;
 » show all
Cath: 3.40.630.170; 3.40.630.30;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.1.97
BRENDA Enzyme Link: BRENDA 2.3.1.97
KEGG Enzyme Link: KEGG2.3.1.97
BioCyc Enzyme Link: BioCyc 2.3.1.97
ExPASy Enzyme Link: ExPASy2.3.1.97
EC2PDB Enzyme Link: EC2PDB 2.3.1.97
ExplorEnz Enzyme Link: ExplorEnz 2.3.1.97
PRIAM enzyme-specific profiles Link: PRIAM 2.3.1.97
IntEnz Enzyme Link: IntEnz 2.3.1.97
MEDLINE Enzyme Link: MEDLINE 2.3.1.97

EC number:2.3.1.97

MSA:

2.3.1.97;
Phylogenetic Tree:

2.3.1.97;
Uniprot:
M-CSA:
RHEA:15521 N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]
RULE(radius=1) [*:1]-[NH2;+0:2].[*:3]=[C;H0;+0:4](-[*:5])-[S;H0;+0:6]-[*:7]>>[*:7]-[SH;+0:6].[*:3]=[C;H0;+0:4](-[*:5])-[NH;+0:2]-[*:1]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Effects of L-histidine and its structural analogues on human N-myristoyltransferase activity and importance of EEVEH amino acid sequence for enzyme activity.Raju RV, Datla RS, Warrington RC, Sharma RK1998 Oct 209778369
N-myristoyltransferase in the leukocytic development processes.Kumar S, Singh B, Dimmock JR, Sharma RK2011 Aug21698528
Kinetic and structural evidence for a sequential ordered Bi Bi mechanism of catalysis by Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase.Rudnick DA, McWherter CA, Rocque WJ, Lennon PJ, Getman DP, Gordon JI1991 May 252033063
Identification and characterization of an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase.Montgomery C, Pei Z, Watkins PA, Miziorko HM2012 Sep 2822865860