Enzyme

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     2. Transferases
        2.3 Acyltransferases
            2.3.2 Aminoacyltransferases
ID:2.3.2.13
Description:Protein-glutamine gamma-glutamyltransferase.
Alternative Name: Transglutaminase.
TGase.
Polyamine transglutaminase.
Glutaminylpeptide gamma-glutamyltransferase.
Fibrinoligase.
Prosite: PDOC00473;
PDB:
PDBScop
5MHO 8055026; 8055027; 8055218; 8055219; 8055402; 8055403; 8055473; 8055474; 8055026; 8055027; 8055218; 8055219; 8055402; 8055403; 8055473; 8055474;
5MHN 8055026; 8055027; 8055218; 8055219; 8055402; 8055403; 8055473; 8055474; 8055026; 8055027; 8055218; 8055219; 8055402; 8055403; 8055473; 8055474;
5MHM 8055026; 8055027; 8055218; 8055219; 8055402; 8055403; 8055473; 8055474; 8055026; 8055027; 8055218; 8055219; 8055402; 8055403; 8055473; 8055474;
5MHL 8055026; 8055027; 8055218; 8055219; 8055402; 8055403; 8055473; 8055474; 8055026; 8055027; 8055218; 8055219; 8055402; 8055403; 8055473; 8055474;
4KTY 8055026; 8055027; 8055218; 8055219; 8055402; 8055403; 8055473; 8055474; 8055026; 8055027; 8055218; 8055219; 8055402; 8055403; 8055473; 8055474;
 » show all

Cath: 1.10.220.130; 3.90.1360.10; 3.90.260.10; 2.60.40.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.2.13
BRENDA Enzyme Link: BRENDA 2.3.2.13
KEGG Enzyme Link: KEGG2.3.2.13
BioCyc Enzyme Link: BioCyc 2.3.2.13
ExPASy Enzyme Link: ExPASy2.3.2.13
EC2PDB Enzyme Link: EC2PDB 2.3.2.13
ExplorEnz Enzyme Link: ExplorEnz 2.3.2.13
PRIAM enzyme-specific profiles Link: PRIAM 2.3.2.13
IntEnz Enzyme Link: IntEnz 2.3.2.13
MEDLINE Enzyme Link: MEDLINE 2.3.2.13
MSA:

2.3.2.13;

Phylogenetic Tree:

2.3.2.13;

Uniprot:
M-CSA:
RHEA:54816 L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)
RULE(radius=1) [*:1]-[CH2;+0:2]-[NH2;+0:3].[*:4]-[NH2;+0:5]>>[*:1]-[CH2;+0:2]-[NH;+0:5]-[*:4].[NH3;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Transglutaminase from rat coagulating gland secretion. Post-translational modifications and activation by phosphatidic acids.Esposito C, Pucci P, Amoresano A, Marino G, Cozzolino A, Porta R1996 Nov 18910321
Transglutaminase-mediated modifications of the rat sperm surface in vitro.Paonessa G, Metafora S, Tajana G, Abrescia P, De Santis A, Gentile V, Porta R1984 Nov 166149619
Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta.Takahashi N, Takahashi Y, Putnam FW1986 Nov2877456
Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome.Ü Basmanav FB, Cau L, Tafazzoli A, Méchin MC, Wolf S, Romano MT, Valentin F, Wiegmann H, Huchenq A, Kandil R, Garcia Bartels N, Kilic A, George S, Ralser DJ, Bergner S, Ferguson DJP, Oprisoreanu AM, Wehner M, Thiele H, Altmüller J, Nürnberg P, Swan D, Houniet D, Büchner A, Weibel L, Wagner N, Grimalt R, Bygum A, Serre G, Blume-Peytavi U, Sprecher E, Schoch S, Oji V, Hamm H, Farrant P, Simon M, Betz RC2016 Dec 127866708
Coagulation Factor XIIIA Subunit Missense Mutations Affect Structure and Function at the Various Steps of Factor XIII Action.Thomas A, Biswas A, Dodt J, Philippou H, Hethershaw E, Ensikat HJ, Ivaskevicius V, Oldenburg J2016 Oct27363989
Purification and molecular characterization of a secretory transglutaminase from coagulating gland of the rat.Seitz J, Keppler C, Hüntemann S, Rausch U, Aumüller G1991 Jun 241676601
Roles of calcium ions in the activation and activity of the transglutaminase 3 enzyme.Ahvazi B, Boeshans KM, Idler W, Baxa U, Steinert PM2003 Jun 2712679341
Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation.Ahvazi B, Kim HC, Kee SH, Nemes Z, Steinert PM2002 May 111980702
The epsilon-(gamma-glutamyl)lysine crosslink and the catalytic role of transglutaminases.Folk JE, Finlayson JS197773346
Mechanism of action of guinea pig liver transglutaminase. I. Purification and properties of the enzyme: identification of a functional cysteine essential for activity.Folk JE, Cole PW1966 Dec 105928192
Molecular and catalytic properties of transglutaminases.Folk JE, Chung SI19734151471