EC number:2.3.2.22
| ID: | 2.3.2.22 |
|---|---|
| Description: | Cyclo(L-leucyl-L-leucyl) synthase. |
| Alternative Name: |
Cyclodileucine synthase. |
| Cath: | 3.40.50.11710; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.2.22 |
| BRENDA Enzyme Link: | BRENDA 2.3.2.22 |
| KEGG Enzyme Link: | KEGG2.3.2.22 |
| BioCyc Enzyme Link: | BioCyc 2.3.2.22 |
| ExPASy Enzyme Link: | ExPASy2.3.2.22 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.2.22 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.2.22 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.2.22 |
| IntEnz Enzyme Link: | IntEnz 2.3.2.22 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.2.22 |
| RHEA:46452 | 2 L-leucyl-tRNA(Leu) = cyclo(L-leucyl-L-leucyl) + 2 H(+) + 2 tRNA(Leu) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[C;H0;+0:3](=[*:4])-[*:5]-[NH2;+0:6].[*:7]-[O;H0;+0:8]-[C;H0;+0:9](=[*:10])-[*:11]-[NH2;+0:12]>>[*:1]-[OH;+0:2].[*:7]-[OH;+0:8].[*:4]=[C;H0;+0:3]1-[*:5]-[NH;+0:6]-[C;H0;+0:9](=[*:10])-[*:11]-[NH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog. | Bonnefond L, Arai T, Sakaguchi Y, Suzuki T, Ishitani R, Nureki O | 2011 Mar 8 | 21325056 |
| Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes. | Gondry M, Sauguet L, Belin P, Thai R, Amouroux R, Tellier C, Tuphile K, Jacquet M, Braud S, Courçon M, Masson C, Dubois S, Lautru S, Lecoq A, Hashimoto S, Genet R, Pernodet JL | 2009 Jun | 19430487 |