Enzyme

Download
EC Tree
     2. Transferases
        2.3 Acyltransferases
            2.3.2 Aminoacyltransferases
ID:2.3.2.5
Description:Glutaminyl-peptide cyclotransferase.
Alternative Name: Glutaminyl-tRNA cyclotransferase.
Glutaminyl cyclase.
Cath: 3.40.630.10;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.2.5
BRENDA Enzyme Link: BRENDA 2.3.2.5
KEGG Enzyme Link: KEGG2.3.2.5
BioCyc Enzyme Link: BioCyc 2.3.2.5
ExPASy Enzyme Link: ExPASy2.3.2.5
EC2PDB Enzyme Link: EC2PDB 2.3.2.5
ExplorEnz Enzyme Link: ExplorEnz 2.3.2.5
PRIAM enzyme-specific profiles Link: PRIAM 2.3.2.5
IntEnz Enzyme Link: IntEnz 2.3.2.5
MEDLINE Enzyme Link: MEDLINE 2.3.2.5
MSA:

2.3.2.5;

Phylogenetic Tree:

2.3.2.5;

Uniprot:
M-CSA:
RHEA:23652 N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)
RULE(radius=1) ([*:1]-[CH;+0:2](-[*:3])-[NH2;+0:4].[*:5]-[NH2;+0:6])>>[*:1]-[CH;+0:2](-[*:3])-[NH;+0:6]-[*:5].[NH3;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes.Busby WH Jr, Quackenbush GE, Humm J, Youngblood WW, Kizer JS1987 Jun 253597387
Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides.Fischer WH, Spiess J1987 Jun3473473
Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding.Huang KF, Liaw SS, Huang WL, Chia CY, Lo YC, Chen YL, Wang AH2011 Apr 821288892
Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.Cynis H, Rahfeld JU, Stephan A, Kehlen A, Koch B, Wermann M, Demuth HU, Schilling S2008 Jun 2018486145
Computational evidence for the catalytic mechanism of glutaminyl cyclase. A DFT investigation.Calvaresi M, Garavelli M, Bottoni A2008 Nov 1518470930
A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.Huang KF, Wang YR, Chang EC, Chou TL, Wang AH2008 Apr 118072935
Isolation and characterization of the glutaminyl cyclases from Solanum tuberosum and Arabidopsis thaliana: implications for physiological functions.Schilling S, Stenzel I, von Bohlen A, Wermann M, Schulz K, Demuth HU, Wasternack C2007 Feb17261077
Papaya glutamine cyclotransferase shows a singular five-fold beta-propeller architecture that suggests a novel reaction mechanism.Guevara T, Mallorquí-Fernández N, García-Castellanos R, García-Piqué S, Ebert Petersen G, Lauritzen C, Pedersen J, Arnau J, Gomis-Rüth FX, Solà M2006 Oct-Nov17081122
Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation.Huang KF, Liu YL, Cheng WJ, Ko TP, Wang AH2005 Sep 1316135565