EC number:2.3.3.1
Enzyme
Download| EC Tree |
| 2. Transferases |
| 2.3 Acyltransferases |
| 2.3.3 Acyl groups converted into alkyl groups on transfer |
3D structure
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1O7X;
4JAG;
4JAF;
4JAE;
4JAD;
4G6B;
1OWC;
1OWB;
1NXG;
1NXE;
5UQS;
4CTS;
3ENJ;
2CTS;
1CTS;
1A59;
6CSC;
5CSC;
6CTS;
5CTS;
4CSC;
3CSC;
2CSC;
1CSS;
1CSR;
1CSI;
1CSH;
1CSC;
1AMZ;
6BOP;
6BOO;
6BON;
6BOM;
6BOL;
5UZR;
5UZQ;
5UZP;
5UQU;
5UQR;
5UQQ;
5UQO;
4YBO;
3O8J;
3HWK;
2R9E;
2R26;
2IFC;
2H12;
2C6X;
1AL6;
1AJ8;
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References
External Links
| UniProtKB Enzyme Link: | UniProtKB 2.3.3.1 |
| BRENDA Enzyme Link: | BRENDA 2.3.3.1 |
| KEGG Enzyme Link: | KEGG2.3.3.1 |
| BioCyc Enzyme Link: | BioCyc 2.3.3.1 |
| ExPASy Enzyme Link: | ExPASy2.3.3.1 |
| EC2PDB Enzyme Link: | EC2PDB 2.3.3.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 2.3.3.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 2.3.3.1 |
| IntEnz Enzyme Link: | IntEnz 2.3.3.1 |
| MEDLINE Enzyme Link: | MEDLINE 2.3.3.1 |
| RHEA:16845 | acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]=[C;H0;+0:6](-[CH3;+0:7])-[S;H0;+0:8]-[*:9].[OH2;+0:10]>>[*:9]-[SH;+0:8].[*:5]=[C;H0;+0:6](-[OH;+0:10])-[CH2;+0:7]-[C;H0;+0:2](-[*:1])(-[*:3])-[OH;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and characterization of citrate synthase from Methylobacterium extorquens--a methylotrophic producer of polyhydroxybutyrate. | Belova LL, Sokolov AP, Morgunov IG, Trotsenko YuA | 1997 Jan | 9113733 |
| Catalytic strategy of citrate synthase: subunit interactions revealed as a consequence of a single amino acid change in the oxaloacetate binding site. | Kurz LC, Shah S, Frieden C, Nakra T, Stein RE, Drysdale GR, Evans CT, Srere PA | 1995 Oct 17 | 7577912 |
| Active site mutants of pig citrate synthase: effects of mutations on the enzyme catalytic and structural properties. | Evans CT, Kurz LC, Remington SJ, Srere PA | 1996 Aug 20 | 8718855 |
| Proposed mechanism for the condensation reaction of citrate synthase: 1.9-A structure of the ternary complex with oxaloacetate and carboxymethyl coenzyme A. | Karpusas M, Branchaud B, Remington SJ | 1990 Mar 6 | 2337600 |