EC number:2.3.3.10

Enzyme

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     2. Transferases
        2.3 Acyltransferases
            2.3.3 Acyl groups converted into alkyl groups on transfer
ID:2.3.3.10
Description:Hydroxymethylglutaryl-CoA synthase.
Alternative Name: Hydroxymethylglutaryl coenzyme alpha-condensing enzyme.
Hydroxymethylglutaryl coenzyme A synthase.
HMG-CoA synthase.
Beta-hydroxy-beta-methylglutaryl-CoA synthase.
Acetoacetyl coenzyme A transacetase.
3-hydroxy-3-methylglutaryl-coenzyme A synthase.
3-hydroxy-3-methylglutaryl-CoA synthase.
3-hydroxy-3-methylglutaryl coenzyme A synthetase.
3-hydroxy-3-methylglutaryl coenzyme A synthase.
3-hydroxy-3-methylglutaryl CoA synthetase.
acetylating).
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-
Prosite: PDOC00942;
PDB:
PDBScop
2WYA
Cath: 3.40.47.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 2.3.3.10
BRENDA Enzyme Link: BRENDA 2.3.3.10
KEGG Enzyme Link: KEGG2.3.3.10
BioCyc Enzyme Link: BioCyc 2.3.3.10
ExPASy Enzyme Link: ExPASy2.3.3.10
EC2PDB Enzyme Link: EC2PDB 2.3.3.10
ExplorEnz Enzyme Link: ExplorEnz 2.3.3.10
PRIAM enzyme-specific profiles Link: PRIAM 2.3.3.10
IntEnz Enzyme Link: IntEnz 2.3.3.10
MEDLINE Enzyme Link: MEDLINE 2.3.3.10

EC number:2.3.3.10

MSA:

2.3.3.10;
Phylogenetic Tree:

2.3.3.10;
Uniprot:
M-CSA:
RHEA:10188 acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H(+)
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]=[C;H0;+0:6](-[CH3;+0:7])-[S;H0;+0:8]-[*:9].[OH2;+0:10]>>[*:1]-[C;H0;+0:2](-[*:3])(-[OH;+0:4])-[CH2;+0:7]-[C;H0;+0:6](=[*:5])-[OH;+0:10].[*:9]-[SH;+0:8]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Isolation and characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl-coenzyme A synthase.Montamat F, Guilloton M, Karst F, Delrot S1995 Dec 298566777
3-Hydroxy-3-methylglutaryl-CoA lyase: expression and isolation of the recombinant human enzyme and investigation of a mechanism for regulation of enzyme activity.Roberts JR, Narasimhan C, Hruz PW, Mitchell GA, Miziorko HM1994 Jul 88027038
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E2013 Dec 324315375
Expression in Haloferax volcanii of 3-hydroxy-3-methylglutaryl coenzyme A synthase facilitates isolation and characterization of the active form of a key enzyme required for polyisoprenoid cell membrane biosynthesis in halophilic archaea.VanNice JC, Skaff DA, Wyckoff GJ, Miziorko HM2013 Sep23794621
Identification and characterization of an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase.Montgomery C, Pei Z, Watkins PA, Miziorko HM2012 Sep 2822865860
Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol.Arnedo M, Menao S, Puisac B, Teresa-Rodrigo ME, Gil-Rodríguez MC, López-Viñas E, Gómez-Puertas P, Casals N, Casale CH, Hegardt FG, Pié J2012 Oct22847177
Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis.Sutherlin A, Hedl M, Sanchez-Neri B, Burgner JW 2nd, Stauffacher CV, Rodwell VW2002 Aug12107122